Study why some water pills stop working in heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This Phase 1 study looks at why “water pills” (diuretics) like bumetanide may not remove fluid as expected in people with heart failure. The results may help clinicians improve treatment strategies for fluid control in the future.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and have a clinical diagnosis of heart failure
- Your heart failure medicines and devices will not be changed (titrated) during the study
- In the past 2 weeks, you have not had any non-planned hospital stays
- You are at your best “dry weight” (not overloaded with fluid), based on symptoms, exam, and weight
- Recent blood tests show potassium is 5.0 or lower and sodium is at least 130
- You must meet the study’s urine test results showing poor response to a 10 mg bumetanide “challenge”
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study looks at why “water pills” sometimes stop relieving fluid overload in people with heart failure. It may help researchers understand the causes of diuretic resistance and improve future treatment for fluid management.
This trial tests whether adding a second type of diuretic (water pill) can help people with heart failure who don't respond well to their current diuretic. It aims to find better ways to manage fluid buildup.
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This trial tests if adding acetazolamide (a water pill) to your usual heart failure treatment can help you lose extra fluid and relieve symptoms. It is for patients recently hospitalized or seen urgently for heart failure worsening.
This trial tests a device to help the kidneys remove excess fluid in people hospitalized for worsening heart failure who are not responding well to standard diuretic (water pill) therapy. It aims to improve heart and kidney function.
This trial tests a new way to adjust diuretic (water pill) doses based on urine sodium levels in patients hospitalized for worsening heart failure. The goal is to improve fluid removal and get patients home sooner.
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