Study why water pills (diuretics) stop working in heart failure
Treatments studied
Part of Heart & circulation clinical trials.
This Phase 1 study looks at why “water pills” sometimes stop relieving fluid overload in people with heart failure. It may help researchers understand the causes of diuretic resistance and improve future treatment for fluid management.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and have a clinical diagnosis of heart failure
- During the study, you will not plan to change heart failure medications or devices (no titration/changes)
- In the past 3 months, you have not had any hospitalizations that were not planned
- Your care team says your fluid level is at your “best” point (dry weight) based on symptoms, exam, and dry weight measurements
- Your kidney function is not severely reduced (you do not have a GFR under 20 or need dialysis/other kidney replacement therapy)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study looks at why “water pills” (diuretics) like bumetanide may not remove fluid as expected in people with heart failure. The results may help clinicians improve treatment strategies for fluid control in the future.
This trial tests whether adding a second type of diuretic (water pill) can help people with heart failure who don't respond well to their current diuretic. It aims to find better ways to manage fluid buildup.
This study looks at how your kidneys handle salt and water when you're treated for acute heart failure in the hospital. Researchers want to understand which patients recover well from fluid buildup and which might need different treatment approaches.
This trial tests a device to help the kidneys remove excess fluid in people hospitalized for worsening heart failure who are not responding well to standard diuretic (water pill) therapy. It aims to improve heart and kidney function.
This trial tests if adding acetazolamide (a water pill) to your usual heart failure treatment can help you lose extra fluid and relieve symptoms. It is for patients recently hospitalized or seen urgently for heart failure worsening.
This study tests whether adding acetazolamide (a different type of water pill) to your current treatment helps remove extra fluid from your body more effectively when you are in the hospital for heart failure.
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