Clin2
NCT06942377Worth exploringNot yet recruiting

Amlodipine for early-stage endometrial cancer in women under 45

Endometrial Cancer

Treatments studied

Part of Cancer, Women’s health & pregnancy clinical trials.

This study tests whether a common blood pressure medication called amlodipine can help treat early-stage endometrial cancer in younger women who want to preserve their fertility. It may be an alternative to hormone therapy, with fewer side effects.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
140 people
Ages
18 years to 45 years
Study type
Interventional

Who can take part

  • You have endometrial adenocarcinoma (a common type of uterine cancer) that is Grade 1 or 2, meaning it is not the most aggressive type.
  • The cancer is only in the inner lining of the uterus or has grown less than halfway into the muscle wall (Stage IA).
  • You are 45 years old or younger.
  • You want to keep your ability to have children in the future.
  • You have never had low blood pressure or fainting episodes more than three times in the last six months.
  • You have not taken other blood pressure medications on a regular basis.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07714070Not yet recruiting· Phase 2
Orlistat plus progestin for fertility-sparing treatment of early endometrial cancer or atypical hyperplasia

This trial tests whether adding the weight-loss drug orlistat to standard hormone therapy can help shrink early-stage endometrial cancer or precancerous changes, so you can avoid having your uterus removed and still try for a baby later.

Beijing, Beijing Municipality
NCT07319429Recruiting· Phase 2/Phase 3
Fertility-sparing treatment for endometrial cancer based on molecular type

This trial tests a tailored approach to preserve fertility in women with early-stage endometrial cancer, using medications like hormones and immunotherapy based on the tumor's molecular subtype. It aims to avoid hysterectomy and keep the uterus intact.

Shanghai, Shanghai Municipality
NCT03463252Recruiting· Phase 2/Phase 3
Hormone IUD to preserve fertility in early uterine cancer

This study looks at whether a hormone-releasing IUD (LNG-IUS) can treat early-stage endometrial cancer or very early abnormal cell growth while helping you keep the option for future pregnancy. It aims to see how well the treatment works and how it affects fertility-related outcomes.

Chengdu, Sichuan
NCT03675893Recruiting· Phase 2
Test abemaciclib plus letrozole with or without extra drugs

This Phase 2 study tests whether adding medicines to standard hormone therapy (letrozole) can control endometrial cancer that has come back, spread, or stopped responding to usual treatments. It also explores whether extra drugs (metformin or gedatolisib) improve results for certain patient groups.

Boston, Massachusetts
NCT06102863Recruiting· Phase 2
Progesterone and statins for young women with early endometrial cancer or atypical hyperplasia

This trial tests whether adding a statin to progesterone therapy helps young women with early endometrial cancer or atypical endometrial hyperplasia who want to preserve their fertility. It aims to find a better treatment option for those who may not respond well to progesterone alone.

Beijing, Beijing Municipality
NCT06468215Recruiting
Fertility-sparing treatment for early stage 2 endometrial cancer

This study tests a way to treat early-stage endometrial cancer without removing the uterus, so you can still have a chance to carry a pregnancy. It’s for women under 45 with a grade 2 tumor that hasn’t grown into the womb muscle.

Beijing, Beijing Municipality

Hear when a new Endometrial Cancer trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.