Short-course radiation plus chemo and immunotherapy for rectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a treatment plan that uses a short course of radiation to the lymph nodes-sparing area, followed by chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of mid or low rectal cancer (pMMR/MSS). The goal is to see if this approach can shrink the tumor and improve outcomes without needing extensive surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with rectal cancer that is pMMR or MSS (a specific type of tumor not typically targeted by immunotherapy alone).
- Your cancer is in the middle or lower part of the rectum and has spread to nearby lymph nodes or into the deeper layers of the bowel wall (stage T3-4N0 or TanyN+).
- You have not had any prior treatment for rectal cancer, such as surgery, radiation, or chemotherapy.
- You are generally healthy enough to undergo radiation and chemotherapy, with good kidney, liver, blood cell counts, and heart function.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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