Shorter radiation with chemo and immunotherapy for high-risk colon cancer
Part of Cancer, Immune system & allergy clinical trials.
This trial tests a shorter course of radiation combined with chemotherapy and an immunotherapy drug (PD-1 inhibitor) for people with a specific type of high-risk colon cancer that has not spread. The goal is to see if this approach can shrink the tumor before surgery and improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 18 and 75 years old.
- You must have colon cancer that has not spread to other organs, but is either stage IIB or III (involving the bowel wall or nearby lymph nodes).
- Your tumor must be a type called pMMR or MSS (which means it is not the kind that usually responds to immunotherapy alone).
- You must be in good enough health to undergo a major surgery to remove the tumor after treatment.
- You cannot have had any previous cancer treatment, including radiation, chemotherapy, or immunotherapy.
- You must be willing to provide blood and tumor tissue samples for research.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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