Testing a new antidepressant combination for depression
Part of Mental health clinical trials.
This study tests a new combination of two medications (dextromethorphan and bupropion) as a treatment for major depressive disorder. It may be an option if you have not already tried many antidepressants that didn't work.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You have been diagnosed with major depressive disorder (MDD) and your current depressive episode has lasted at least 4 weeks.
- You have not tried 2 or more different antidepressants that did not work for your current depression.
- You are not currently at risk of harming yourself or others.
- You do not have a history of seizures, eating disorders, or uncontrolled high blood pressure.
- You are not allergic to bupropion, dextromethorphan, or related medications.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a combination medication (dextromethorphan plus bupropion) to see how it affects brain activity in people with moderate-to-severe depression. Researchers use brain imaging (fMRI) to understand how the drug works and whether it may help relieve depression symptoms.
This study tests a new antidepressant tablet against an approved one to see which works better and is safer for adults with major depression. It may help find a more effective option for treating depressive symptoms.
This trial tests an investigational medication for adults with major depressive disorder who are currently taking an antidepressant but still have symptoms. It aims to see if adding this new drug can improve mood better than a placebo.
This study tests a new medicine called ammoxetine for people with major depression. It aims to see if it can help reduce depressive symptoms.
This study tests an investigational drug called KH607 for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms over time. Participants must stop other depression medications before starting and will be monitored closely.
This study tests an investigational medication (CYB003) for people with major depression whose current antidepressant isn't working well enough. It looks at whether this treatment can help improve depression symptoms.
Hear when a new Major Depressive Disorder (MDD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.