Treating stroke beyond 24 hours with artery-opening procedure
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether opening a blocked large artery in the brain up to 5 days (or even 7 days if symptoms are worsening) after a stroke can improve outcomes. It uses a catheter-based treatment (endovascular therapy) for people who have not responded to standard care and have limited brain damage so far.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your stroke symptoms started between 24 hours and 5 days ago (or up to 7 days if symptoms were getting worse).
- Your stroke symptoms are rated moderate to moderately severe (NIHSS score 5–25).
- Brain scans show a severe blockage (70% or more) in the carotid or middle cerebral artery, but the stroke damage is not too extensive.
- You have not had a prior stroke that left you with significant disability (mRS score less than 2).
- You do not have conditions that increase bleeding risk, like low platelets, blood thinner use with high INR, or recent bleeding in the brain.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a specific treatment (likely endovascular therapy) helps people who have a minor stroke caused by a blockage in a large brain artery. If you are eligible, you may receive this treatment within 24 hours of your stroke to try to improve your recovery.
This study tests a procedure called endovascular recanalization, which uses a small tube to open a blocked artery in the brain. It is for people who had a stroke or mini-stroke recently and are still having symptoms despite taking medication. The goal is to improve blood flow and reduce the chance of another stroke.
This trial tests a precise treatment to restore blood flow in people who had a mild but disabling stroke up to 24 hours earlier, using mechanical clot removal or clot-busting medication. The goal is to reduce long-term disability by reopening the blocked vessel while protecting healthy brain tissue.
This trial compares a procedure to remove a blood clot from a brain artery (endovascular therapy) with standard medicines alone, for people who had a large-vessel stroke more than 24 hours ago (up to 30 days). It aims to see if the procedure can still help improve recovery even after this longer time window, especially if symptoms are fluctuating or worsening.
This trial tests whether cooling the brain and reopening a blocked major artery can improve recovery after a severe stroke. It is for people who have had a large stroke and may benefit from this combination treatment.
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