New drug combo vs chemo for advanced lung cancer after EGFR treatment fails
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a combination of two experimental drugs (vebreltinib plus PLB1004) against standard chemotherapy for people with a specific type of advanced lung cancer (EGFR mutation positive, MET positive) that has gotten worse after prior EGFR-targeted therapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have advanced or spread lung cancer (stage IIIB or IV) with an EGFR mutation and MET positive status.
- You've already tried an EGFR-blocking drug, and it stopped working.
- You are at least 18 years old and able to give consent.
- You must have at least one tumor that can be measured on scans.
- You are in generally good physical condition (ECOG 0 or 1) and not pregnant or nursing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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