Clin2
NCT07010146Possibly a fitRecruiting

Estrogen's Effect on Bone Health in FHA

Bone StrengthBone DensityFHA (Functional Hypothalamic Amenorrhea)

Part of Bones, joints & muscles, Hormones & metabolism, Women’s health & pregnancy clinical trials.

This study tests how estrogen treatment affects bone strength in young women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress, low weight, or over-exercise. Participants who have had very few periods will receive estrogen to see if it improves bone density.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
150 people
Ages
14 years to 30 years
Study type
Interventional

Who can take part

  • You must be female, between 14 and 30 years old, and finished with most of your bone growth (bone age at least 14).
  • If you could become pregnant, you need to use a non-hormonal birth control method or a progestin-releasing IUD during the study.
  • You must have had fewer than 3 menstrual periods in the last 6 months.
  • Your blood tests show normal thyroid, prolactin, potassium, liver, and cholesterol levels.
  • You cannot have other conditions that affect bone (like untreated thyroid disease, diabetes, or kidney failure) or take bone-altering medications.
  • You cannot be pregnant, planning pregnancy soon, or breastfeeding, and your BMI must be under 25.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06533865Recruiting· Phase 3
Romosozumab and estrogen for bone loss from missed periods

This study tests whether a bone-building medication (romosozumab) combined with estrogen replacement therapy can improve bone density in young women with hypothalamic amenorrhea (missing periods due to low energy or stress). It aims to find a better treatment for low bone density caused by this condition.

Boston, Massachusetts
NCT06683222Recruiting
How muscle and bone talk to each other in healthy women

This study looks at how signals from muscles affect bone health in women of different ages. It aims to understand why bone density changes over time.

Montpellier
NCT05704036Recruiting· Phase 4
Estrogen use and bone health in women with cystic fibrosis

This observational study looks at how taking (or not taking) estrogen affects bone health in women with cystic fibrosis (CF). If you may have low estrogen, it also explores whether estrogen levels and symptoms relate to bone density over time.

Baltimore, Maryland
NCT06851754Recruiting· Phase 3
Hormone therapy for teens with early menopause

This trial tests whether hormone replacement therapy (HRT) helps protect bone health in teenagers with premature ovarian insufficiency (POI). It compares HRT to a placebo and also includes healthy volunteers for comparison.

Bethesda, Maryland
NCT03875378Recruiting· Phase 2
Transdermal estrogen treatment for anorexia-related bone loss

This trial studies whether estrogen delivered through the skin can help improve bone health in women with anorexia nervosa. It may be considered if your body weight is low and you have signs of bone thinning.

Pittsburgh, Pennsylvania
NCT07612735Not yet recruiting
Resistance training for women with missed periods

This study tests whether an 8-week supervised strength training program can help women with functional hypothalamic amenorrhea (a condition where periods stop due to stress, low energy, or intense exercise) resume regular menstrual cycles. It compares results with women who have normal cycles.

Murcia, Murcia

Hear when a new Bone Density trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.