Study of ASP2138 before surgery for pancreatic cancer
Treatments studied
Part of Cancer clinical trials.
This study tests an experimental drug, ASP2138, given before surgery for pancreatic cancer that is still removable. After surgery, you will receive standard chemotherapy. The goal is to see if adding ASP2138 before surgery helps improve outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your pancreatic cancer must be the type that can be removed with surgery, and you must not have had any treatment for it yet.
- Your tumor must test positive for a protein called claudin 18.2 (CLDN18.2), which the study drug targets.
- You must be able to have surgery and then chemotherapy after surgery, as part of your standard care.
- You should be in generally good health (able to do most daily activities) and have no serious heart problems in the last 6 months.
- Women who could become pregnant must use effective birth control for 6 months after the last dose of the study drug, and men must also use contraception.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study looks at specific body chemistry pathways in pancreatic cancer tissue to better understand what may help treatment work. If you are having pancreatic surgery, the researchers will take extra small tissue samples during the operation to study tumor and normal tissue.
This trial tests a light-activated drug called ASP-1929 for people with locally advanced pancreatic cancer who have completed chemotherapy before surgery. The drug targets cancer cells and is activated by a special light during surgery.
This Phase 1 trial tests ASP2138 alone or with other cancer medicines in adults with stomach (including GEJ) or pancreatic cancer. You may be eligible if your tumor has a specific protein marker and your health tests and scan results meet safety requirements.
This Phase 2 trial tests a chemotherapy plan given before surgery (called “neoadjuvant” treatment) for people with pancreatic adenocarcinoma that looks resectable or borderline resectable on scans. The goal is to see how well this adaptive chemotherapy approach works and whether it can improve outcomes before an operation.
This trial tests a new drug called ASP546C in people with certain advanced cancers that have a specific marker (CLDN18.2). It aims to see if the drug can shrink or slow tumor growth.
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