Comparing a new drug to chemo for advanced endometrial cancer
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial tests a new investigational drug called Puxitatug Samrotecan (AZD8205) against standard chemotherapy in people whose endometrial cancer has come back or spread after prior treatment with platinum chemo and an immunotherapy. The goal is to see if the new drug works better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with endometrial cancer or carcinosarcoma.
- Your cancer has come back or spread and you have already tried platinum-based chemotherapy and an immunotherapy (PD-1/PD-L1 blocker).
- You are well enough to be up and about (ECOG score 0 or 1).
- Your cancer can be measured on scans (like CT or MRI).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 1/2 study tests targeted drug(s) for endometrial cancer that has come back or never fully went away after prior treatments. You may be eligible if your tumor can be tested for specific biomarkers and your health allows treatment safely.
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