New drug vs standard chemo for HER2-positive endometrial cancer
Treatments studied
Part of Cancer, Women’s health & pregnancy clinical trials.
This trial compares a new targeted medicine (trastuzumab deruxtecan) against standard chemotherapy for women with a certain type of advanced endometrial cancer that has high levels of HER2 protein. It's for people whose cancer is newly diagnosed and has spread to nearby tissues but not to distant organs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have been diagnosed with a type of endometrial cancer that is not a sarcoma (carcinosarcoma is allowed).
- Your cancer is newly diagnosed and is at a stage called Stage IIC or Stage III (not stage IV or cancer that has come back after treatment).
- A central lab has confirmed that your cancer cells have high levels of HER2 protein (a score of 2+ or 3+).
- You have a tumor tissue sample from surgery available for testing.
- You do not have certain heart or lung conditions, or a history of serious lung inflammation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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