Tezepelumab for severe asthma with or without nasal polyps
Treatments studied
Part of Immune system & allergy, Lungs & breathing clinical trials.
This trial tests if Tezepelumab improves lung and sinus barrier function in people with severe asthma. It includes those who also have chronic sinusitis with nasal polyps, to see if the drug helps both conditions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 99 years old.
- You have a doctor's diagnosis of severe asthma that is not well-controlled despite high-dose inhalers.
- You have had either high levels of eosinophils (a type of white blood cell) in your blood or sputum, or a high FeNO (a measure of airway inflammation).
- You have not used a biologic (targeted antibody) for asthma or polyps in the last 3 months (or longer if the drug's half-life is longer).
- You are not pregnant, do not have other serious lung diseases, and have not smoked in at least 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tracks how well tezepelumab works for people with chronic sinusitis and nasal polyps in real-world settings. It aims to see if this medication reduces symptoms and the need for surgery.
This study follows patients with chronic rhinosinusitis with nasal polyps (CRSwNP)—a condition causing blocked sinuses and nasal growths—who are starting a new biologic medication called tezepelumab. Researchers will track how symptoms and quality of life improve over time in everyday medical practice.
This study watches how well tezepelumab (Tezspire) works in real life for people who are already taking it for approved reasons. It collects information to make sure the medicine is safe and effective outside of a clinical trial.
This trial tests a new injectable medicine (lebrikizumab) for people with chronic sinusitis and nasal polyps that steroid treatments haven't controlled. It aims to reduce polyp size and improve breathing, smell, and congestion.
This trial tests an investigational medication called AK139 for people with chronic sinusitis and nasal polyps. The treatment aims to reduce nasal congestion and polyp size, potentially improving symptoms.
This trial compares a newer biologic drug (anti-IL-5) plus simple polyp removal to a more extensive sinus surgery. It's for people with chronic sinusitis and nasal polyps who haven't gotten better with standard treatments.
Hear when a new Asthma Bronchiale trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.