Tezepelumab and airway barrier function in severe asthma
Treatments studied
Part of Immune system & allergy, Lungs & breathing clinical trials.
This study is testing a medicine called tezepelumab to see how it affects the lining (barrier) of the airways in people with severe asthma, with or without nasal polyps. Tezepelumab is given as an injection and may help reduce inflammation and improve asthma control.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 99 years old
- You have a confirmed diagnosis of asthma
- You are on step 4 or 5 asthma treatment, which usually means high-dose inhaled steroids with a long-acting inhaler (ICS/LABA)
- Your asthma is not well controlled despite this treatment – for example, you have frequent symptoms, need oral steroids often, have been hospitalized for asthma, or your lung function is below 80%
- You have a blood test showing eosinophils (a type of white blood cell) at 250 or more per microliter, or if you are on oral steroids, at least 150 – or you have sputum/lung wash eosinophils above 2%
- You have a mucus score of at least 1 and, for the group with polyps, confirmed nasal polyps by endoscopy or CT
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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