Experimental drug for advanced colorectal cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new experimental drug (HNF4α srRNA) given through a vein for people with advanced colorectal cancer that has not responded to or cannot be treated with standard therapies. The goal is to see if this treatment can help shrink or slow the growth of the cancer.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have been diagnosed with colorectal cancer that has spread or cannot be removed by surgery.
- You have tried standard treatments (like chemotherapy or targeted therapy) and they no longer work, or you cannot take them because of side effects.
- You have at least one tumor that can be measured on a scan (but not one that was previously treated with surgery or radiation, unless it has clearly grown).
- Your overall health is good enough to perform daily activities (ECOG score 0-2), and your doctor expects you to live at least 12 more weeks.
- You are not pregnant or breastfeeding, and if you are of childbearing age, you agree to use effective birth control during and for 6 months after treatment.
- You do not have certain serious health problems like uncontrolled infections, autoimmune diseases, or cancer that has spread to the brain.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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