Clin2
NCT07059494Possibly a fitRecruiting

Combination therapy for liver cancer before transplant

Hepatocellular Carcinoma

Treatments studied

Part of Cancer, Digestive system clinical trials.

This trial tests a combination of two drugs (atezolizumab and bevacizumab) plus a targeted radiation treatment (Y-90 radioembolization) for people with liver cancer who are waiting for a liver transplant. The goal is to see if this treatment can help control the cancer and improve transplant outcomes.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
40 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older.
  • You have newly diagnosed liver cancer (HCC) confirmed by biopsy.
  • Your tumor is either larger than standard limits (Milan criteria) or within those limits but with a high alpha-fetoprotein (AFP) level (≥400 ng/mL).
  • Your cancer has not spread to blood vessels or other parts of the body.
  • Your liver function is good enough (Child-Pugh score A or B7 without fluid in the belly).
  • You are healthy enough for daily activities (ECOG score 0 or 1).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05185505Enrolling by invitation· Phase 4
Immunotherapy before liver transplant for advanced liver cancer

This trial tests whether giving a combination of two immunotherapy drugs before a liver transplant can help people with advanced liver cancer (beyond standard size limits) receive a transplant successfully. The treatment aims to shrink the tumor and improve outcomes.

Houston, Texas
NCT06867432Not yet recruiting· Phase 2
Combination radiation, immunotherapy, and targeted therapy for liver cancer

This trial tests a new combination for liver cancer that cannot be surgically removed yet. It uses tiny radioactive beads (yttrium-90) to deliver radiation directly to the tumor, along with immunotherapy drugs and a targeted therapy to shrink the tumor, with the hope that it can later be surgically removed.

NCT06339424Recruiting· Phase 2
Atezolizumab and Bevacizumab with radiation for liver cancer that can't be removed

This trial tests adding two immunotherapy and anti-angiogenesis drugs (atezolizumab and bevacizumab) to standard photon radiation for people with liver cancer that cannot be surgically removed. It aims to see if this combination can shrink tumors and improve outcomes.

Taoyuan City, Taiwan
NCT05992220Recruiting· Phase 2
Immunotherapy with or without radiation for liver cancer

This trial tests a combination of two immunotherapy drugs (atezolizumab and bevacizumab) with or without targeted radiation therapy for liver cancer that has invaded the major blood vessels of the liver. The goal is to see if adding radiation helps shrink tumors or slow the disease.

Seoul
NCT07281664Not yet recruiting
Combination treatment for advanced liver cancer

This trial tests a combination of treatments for liver cancer that cannot be removed with surgery. It uses a procedure to block the tumor's blood supply plus two drugs that help the immune system fight the cancer. This may help shrink tumors and slow the disease.

NCT06725121Recruiting· Phase 1/Phase 2
Radiation and immunotherapy for advanced liver cancer before transplant

This trial tests combining radiation therapy with immunotherapy (AtezoBev) before a liver transplant for advanced liver cancer. The goal is to see if this approach can shrink tumors and make transplant possible for more people.

London, Ontario

Hear when a new Hepatocellular Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.