Organ preservation for low rectal cancer after chemo
Part of Cancer, Digestive system clinical trials.
This trial tests whether chemotherapy alone can help avoid surgery for low rectal cancer. It is for people with tumors close to the anus that haven't spread far, and who haven't had prior cancer treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 80 years old.
- You have rectal cancer that is confirmed by biopsy and is a type called pMMR or MSS.
- Your tumor is within 5 cm of the anal opening and is not too large or deep.
- You have not had surgery, radiation, or chemotherapy for this cancer before.
- Your liver, kidney, and blood counts are within normal ranges.
- You are not allergic to 5-FU or platinum drugs, and you agree to use birth control if needed.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a program that helps you and your doctor decide together whether to avoid surgery and keep your rectum after chemo and radiation. It's for people with early-stage rectal cancer who have not had prior treatment for this cancer.
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This trial compares two ways to preserve the rectum/avoid major surgery after radiation: a focused contact x-ray treatment versus waiting longer and then removing only a small area if needed. It may help some people keep more normal bowel function while still controlling the cancer.
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