Clin2
NCT07071636Possibly a fitNot yet recruiting

Combination treatment for chronic hepatitis B

Metabolic Dysfunction-Associated Steatotic Liver DiseaseChronic Hepatitis B

Part of Digestive system, Infections clinical trials.

This study tests a combination of two medicines for chronic hepatitis B: pegylated interferon and a nucleoside analogue. The goal is to see if this combo helps clear the hepatitis B surface antigen and improves the chance of a functional cure.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
830 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You are between 18 and 65 years old
  • You have been hepatitis B surface antigen (HBsAg) positive for at least 6 months
  • You are negative for hepatitis B 'e' antigen (HBeAg)
  • Your HBsAg level is 1500 IU/mL or lower
  • You do not have metabolic fatty liver disease (for example, you are not overweight, do not have diabetes, high blood pressure, or high cholesterol)
  • You are not pregnant or breastfeeding, and you do not drink excessive alcohol

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06368882Recruiting· Phase 4
Peg-interferon for hepatitis B with fatty liver

This trial tests a medicine called peg-interferon for people who have both chronic hepatitis B and fatty liver. It aims to see if the treatment is safe and effective in helping your body fight the hepatitis B virus.

Ningbo
NCT07809165Not yet recruiting
Combination treatment for chronic hepatitis B

This trial tests a new way to treat chronic hepatitis B in patients already taking antiviral medication. It combines a drug that helps the immune system fight the virus with another drug that boosts the immune response, aiming to improve chances of clearing the virus.

Jinan
NCT05771402Recruiting· Phase 2
Combination treatment aimed at clearing hepatitis B long-term

This Phase 2 study tests a combination treatment to help people with chronic hepatitis B stop having detectable hepatitis B surface antigen (called HBsAg). If successful, it may move you closer to a “functional cure,” meaning lower ongoing virus activity over time.

Chongqing, Chongqing Municipality
NCT07537387Not yet recruiting
Retreatment for hepatitis B after prior interferon therapy

This trial tests a retreatment with pegylated interferon for people with chronic hepatitis B who have previously received interferon therapy and have seen their hepatitis B surface antigen (HBsAg) levels drop by at least half. The goal is to see if this retreatment can completely clear the virus from the blood.

Shanghai
NCT07573943Recruiting· Phase 4
ASC22 with Peg-IFN for chronic hepatitis B cure

This study tests whether a combination of two drugs (ASC22 and Peg-IFN) can help people with chronic hepatitis B achieve a functional cure. The goal is to see if this therapy can clear the virus and improve liver health.

Chongqing, Chongqing Municipality
NCT06777173Enrolling by invitation
Antiviral and Immunotherapy for Chronic Hepatitis B

This study tests a new combination of antiviral medicine and an immune-boosting therapy for adults with chronic hepatitis B. It is designed for people who are in the active phase of the infection and have not been treated before.

Beijing

Hear when a new Metabolic Dysfunction-Associated Steatotic Liver Disease trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.