Endoscopic sinus expansion plus Stapokibart for chronic sinusitis
Part of Ear, nose & throat clinical trials.
This trial tests if a new drug (Stapokibart) combined with a sinus surgery improves symptoms like nasal congestion, discharge, and loss of smell in people with type 2 chronic sinusitis.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had chronic sinusitis for more than 2 years with symptoms like stuffy nose, discharge, and headache or reduced smell.
- Tests show signs of type 2 inflammation (e.g., high eosinophils or IgE levels), and you have at least 3 of 5 criteria including need for steroids, poor quality of life, loss of smell, or asthma.
- You are between 18 and 75 years old.
- You live in Northeast China (Heilongjiang, Jilin, Liaoning, or certain Inner Mongolia areas) or Southern China (Guangdong or Guangxi) and can follow up at the enrolling hospital.
- You have not had sinus surgery or used allergen immunotherapy or biological drugs in the past year.
- You do not have severe uncontrolled diabetes, heart disease, or other conditions that prevent surgery, and you are not pregnant.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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