Personalized vaccine for recurrent glioma
Part of Cancer clinical trials.
This trial tests a personalized vaccine created by AI to target your specific brain tumor. It is for people with a glioma that came back after standard treatments like surgery, radiation, or chemotherapy, and whose tumor has enough genetic mutations to make the vaccine.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a glioma (a type of brain tumor) that came back after standard treatments like surgery, radiation, or chemotherapy.
- Your tumor must have many genetic changes (high mutation load) and at least 10 new targets (neoantigens) for the vaccine to recognize.
- You must be able to give a sample of your tumor and blood for testing.
- You need to have at least one tumor that can be seen on an MRI scan.
- You should be in fairly good health (able to care for yourself and with good blood, liver, and kidney function).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial is for people with glioma who have tumor tissue or blood samples stored. It uses artificial intelligence to analyze these samples and find the best treatment. You might be eligible if you are at least 18 years old and have had a glioma diagnosis with tissue available for study.
This trial tests a personalized vaccine made from your own immune cells (dendritic cells) to treat glioblastoma that has come back after standard treatment. The vaccine is designed to help your immune system recognize and attack your tumor.
This early-stage study tests a personalized cancer vaccine designed to prevent glioblastoma (a serious brain tumor) from coming back after surgery and standard treatment. The vaccine aims to train your immune system to recognize and attack any remaining cancer cells.
This trial tests a personalized DNA vaccine made from your tumor’s DNA (neoantigens) to help your immune system fight the cancer. It is designed for children and young adults with certain recurrent or newly diagnosed brain/spine tumors, after they have had other standard treatments and tumor tissue is available for testing.
This trial tests a personalized vaccine (made from your own immune cells and tumor 'neoantigens') combined with the chemotherapy drug temozolomide for people with newly diagnosed glioblastoma. The goal is to see if adding the vaccine helps the immune system better fight the tumor.
This study tests a combination treatment for glioblastoma, a type of brain cancer. It includes a personalized vaccine made from your tumor, along with chemotherapy and an immunotherapy drug (anti-PD-1). The goal is to see if this combination helps people with this cancer.
Hear when a new Glioma trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.