Nasal fentanyl for pain relief during ROP eye exams in premature babies
Treatments studied
Part of Brain & nervous system, Eyes & vision, Genetic & congenital, Pain, Women’s health & pregnancy clinical trials.
This study tests a new way to give a nasal spray of fentanyl (a strong painkiller) to premature babies before their routine eye exams for ROP. It aims to see if this medicine reduces pain and discomfort during the exam better than current standard care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Baby born at or before 31 weeks of pregnancy, or weighed less than 1250 grams at birth
- Baby is scheduled for routine eye exams for retinopathy of prematurity (ROP) as part of their NICU care
- Baby is stable (no need for emergency breathing help in the last 24 hours, and heart rate and breathing are steady)
- Parent or legal guardian can give written permission for the baby to join
- Baby does not have any birth defects or conditions affecting the nose that would make the nasal spray hard to give
- Baby has not received strong pain or sedation medications in the last 24 hours, and is not allergic to fentanyl
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests two medicines (fentanyl for pain and rocuronium for muscle relaxation) to see which works better for placing a breathing tube in newborns. The goal is to make the procedure safer and more comfortable for your baby.
This study tests two drug-free methods to help reduce pain when premature babies get a special eye exam for retinopathy of prematurity. It may help your baby feel more comfortable during the procedure.
This study compares two different nasal spray pain medicines (sufentanil and ketamine) to see which works better and is safer for children with severe pain from injuries, like a broken arm or leg.
This trial tests a nebulized (inhaled mist) form of fentanyl in healthy volunteers to see how it works in the body. It is a first-in-human study of the drug given through a nebulizer, which might help people with acute pain in the future.
This trial compares giving fentanyl as a nasal spray versus an injection to help preterm babies during painful procedures like placing a central line, inserting a breathing tube, or a spinal tap. The goal is to see which method works better and is safer.
This trial tests whether a medicine called midazolam, given as nose drops, helps reduce stress and pain in premature babies during the routine eye exam for retinopathy of prematurity (an eye problem in premature babies). If your baby is eligible, they may receive this medicine during the exam to make it more comfortable.
Hear when a new Neonatal Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.