Comparing stool transplant, fidaxomicin, and vancomycin for C. diff infection
Treatments studied
Part of Infections clinical trials.
This trial compares three treatments for Clostridioides difficile infection (a severe diarrhea caused by bacteria) to see which works best and prevents it from coming back. It tests a fecal microbiota transplant (FMT, transferring healthy donor stool), fidaxomicin, and vancomycin, all given by mouth or tube.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 65 or older, or between 18 and 64 with certain health conditions or risk factors
- You have a confirmed C. diff infection with diarrhea and positive test results
- You have not been treated for this infection for more than 24 hours before starting
- Your white blood cell count is high enough (above 500) within the last 3 days
- You can swallow large capsules or are okay with a tube procedure for FMT
- You understand and agree to participate in the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two medicines, fidaxomicin and vancomycin, to see which one is better at preventing C. diff infection in people with inflammatory bowel disease who are having a colonoscopy.
This study follows patients who were treated for a C. difficile infection (a serious gut bacteria infection) at Umeå University Hospital to compare how well they recover long-term with either a fecal microbiota transplant (FMT—transferring healthy gut bacteria from a donor) or antibiotic treatment alone.
This trial tests whether giving a stool transplant (also called FMT) can treat a new, early C. difficile infection in people who have improved while on antibiotics. It may help some people prevent the infection from coming back or worsening.
This study tests whether taking a capsule form of fecal microbiota transplant (FMT) can help adults with their first C. difficile infection—or a first relapse—get better and reduce repeat episodes. Participants also take specific antibiotics for C. difficile as part of the study process.
This trial studies whether fecal microbiota transplantation (a procedure that transfers healthy stool bacteria) can change a person’s gut bacteria after repeated C. difficile infection. It may help reduce recurring infections by restoring a healthier balance of gut microbes.
This study tests if a freeze-dried fecal transplant (FMT) can help people with difficult-to-treat diarrhea caused by IBS-D or recurring C. diff infections. It's a way to restore healthy gut bacteria and may reduce symptoms.
Hear when a new Clostridioides Difficile Infection trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.