Comparing treatments for C. diff infection to stop it from returning
Treatments studied
Part of Infections clinical trials.
This trial compares three treatments for a severe diarrhea infection called C. diff: a fecal transplant (putting healthy donor stool into your gut), a newer antibiotic called fidaxomicin, and an older antibiotic called vancomycin. The goal is to see which works best and prevents the infection from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 65 years or older, or between 18 and 64 with certain health conditions or risk factors (like recent hospital stay, other antibiotics, or stomach acid pills).
- You have a confirmed C. diff infection causing diarrhea (more than 3 loose stools in 24 hours).
- You have not taken more than 24 hours of standard C. diff antibiotics (vancomycin, metronidazole, or fidaxomicin) before starting this trial.
- You have a healthy enough immune system (your white blood cell count is not too low).
- You can swallow large capsules, or you are okay with getting the treatment through a tube into your stomach or intestines.
- You have a life expectancy of at least 3 months and no other known causes of diarrhea.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study is looking at people who were treated for C. diff (a serious gut infection) at Umeå University Hospital to see how they are doing years later. It compares people who got a fecal transplant (a treatment that restores healthy gut bacteria) with those who only took antibiotics.
This study tests whether taking a capsule form of fecal microbiota transplant (FMT) can help adults with their first C. difficile infection—or a first relapse—get better and reduce repeat episodes. Participants also take specific antibiotics for C. difficile as part of the study process.
This study tests two antibiotics—fidaxomicin and vancomycin—to see which is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease. If you are having a colonoscopy, you may be able to participate.
This trial tests if capsules containing fecal microbiota can prevent further Clostridioides difficile infections in people who have had at least two recurrences. If you've had multiple C. diff infections and your symptoms go away with antibiotics, this treatment might help keep them from coming back.
This trial studies whether fecal microbiota transplantation (a procedure that transfers healthy stool bacteria) can change a person’s gut bacteria after repeated C. difficile infection. It may help reduce recurring infections by restoring a healthier balance of gut microbes.
This study tests a freeze-dried fecal microbiota transplant (FMT) to see if it helps with diarrhea-predominant irritable bowel syndrome (IBS-D) or prevents repeat C. diff infections. FMT introduces healthy bacteria into your gut to restore balance.
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