Clinical trials
Clostridioides Difficile Infection clinical trials
Below are recruiting clostridioides difficile infection clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07513285RecruitingPhase 2
Ibezapolstat pill for recurrent C. difficile infection
This trial tests a new oral antibiotic called ibezapolstat to treat recurrent C. difficile infection (CDI)—a serious diarrheal illness caused by bacteria in your gut. The study focuses on patients who have had multiple CDI episodes and may benefit from a different treatment approach.
Sacramento, CaliforniaAges 18–90 - NCT03895593Recruiting
Fecal transplant for stubborn intestinal infections
This study looks at “rescue” fecal microbiota transplantation (FMT), which replaces gut microbes using stool from a screened donor, for intestinal infections that have not improved with standard care. It may help patients whose infection keeps coming back or doesn’t respond to treatment.
Nanjing, JiangsuAges Any age - NCT07285213RecruitingPhase 2
Preventing C. diff return with an antibody
This study tests a new antibody (AZD5148) to prevent C. diff infection from coming back. If you have a current C. diff infection and are being treated with antibiotics, you may be able to join.
Phoenix, ArizonaAges 18 years+ - NCT04305769RecruitingPhase 2
Alanyl-glutamine to help treat C. difficile diarrhea
This study tests whether the supplement alanyl-glutamine, given along with standard treatment, can improve outcomes for adults being treated for C. difficile infection (a cause of diarrhea). It may help the body recover better after antibiotics that usually treat C. difficile.
Charlottesville, VirginiaAges 18–105 - NCT05266807RecruitingPhase 3
Capsule fecal transplant to prevent C. difficile coming back
This study tests whether taking a capsule form of fecal microbiota transplant (FMT) can help adults with their first C. difficile infection—or a first relapse—get better and reduce repeat episodes. Participants also take specific antibiotics for C. difficile as part of the study process.
Basel, BaselAges 18 years+ - NCT06030245Recruiting
Tracking recovery from C. diff infection in hospital patients
This study follows patients with Clostridioides difficile (C. diff) infection to see how their symptoms improve and when the bacteria clear from their body. It aims to better understand recovery and guide treatment.
ParisAges 18 years+ - NCT06106698Recruiting
Washed microbiota transplant for C. diff infection
This trial tests a treatment called washed microbiota transplantation (WMT) for people with a C. diff infection that causes diarrhea. WMT uses processed donor bacteria to help restore healthy gut balance and fight the infection.
Nanjing, JiangsuAges 3–100 - NCT06237452RecruitingPhase 3
VE303 to prevent repeat C. diff infections
This trial tests a new medicine called VE303, a live bacterial therapy, to prevent C. diff infections from coming back. It is for people who have had C. diff at least once in the last 6 months, or who are at high risk for a repeat infection due to age or other health problems.
Huntsville, AlabamaAges 12 years+ - NCT07613645Recruiting
Lifestyle changes to prevent recurring C. difficile infection
This study tests whether specific lifestyle changes during treatment for C. difficile infection (a serious gut bacteria infection) can help prevent it from coming back. You'll receive standard antibiotic treatment and follow a controlled diet while researchers track your recovery.
Ann Arbor, MichiganAges 18 years+ - NCT06306014RecruitingPhase 1/Phase 2
Study of a new therapy to prevent C. diff recurrence
This study tests a new live bacteria product (EXL01) given with vancomycin to prevent C. diff from coming back. It is for people who have already had C. diff two or more times and are at high risk of another infection.
AnnecyAges 18 years+ - NCT06788769Recruiting
C. difficile study in babies 0 to 2 years
This study looks at C. difficile bacteria in babies up to 2 years old. It compares babies with C. difficile infection, carriers without symptoms, and healthy babies to understand how the bacteria affects them.
Hangzhou, ZhejiangAges 1 day–2 years - NCT06859437Recruiting
Preventing C. diff infection with a probiotic in transplant patients
This trial tests whether a probiotic called Lactobacillus plantarum can help prevent Clostridium difficile (C. diff) infections in people who have had an organ transplant or are on immune-suppressing drugs and are taking antibiotics. If you qualify, you may get a probiotic that could reduce your risk of this serious gut infection.
Poland, Silesian VoivodeshipAges 18 years+ - NCT06979609RecruitingPhase 2/Phase 3
Preventing C. diff infection with vancomycin
This trial tests whether taking vancomycin by mouth can prevent another C. diff infection when you need to take other antibiotics. It’s for patients who recently had C. diff and are about to start a new antibiotic course.
Montreal, QuebecAges 18 years+ - NCT07221370RecruitingPhase 2/Phase 3
Vancomycin to prevent C. diff infection in ICU patients
This trial tests whether giving vancomycin through a tube into the stomach can prevent a serious gut infection called C. diff in people who are very sick in the ICU and taking antibiotics. If you qualify, you might receive this medicine to lower your risk.
Moreno Valley, CaliforniaAges 18 years+ - NCT07374094Recruiting
Understanding C. difficile infection and treatment effects
This study is tracking patients with a confirmed C. difficile infection to understand how the body responds and how treatments work. You may be asked to do follow-up visits for up to 5 years.
UmeåAges 18 years+ - NCT05389904Recruiting
Prevent C. difficile infection in high-risk hospital patients
This trial tests whether giving prevention right away can stop C. difficile infection from developing in people identified as high risk after a VRE swab. It may help reduce stomach infection and serious complications during hospital stay.
Boston, MassachusettsAges 18 years+ - NCT07250724Recruiting
C. diff Toxin Levels After Antibiotic Treatment
This study looks at levels of C. diff toxins in stool after standard antibiotic treatment. It aims to understand how toxins change during recovery, which may help improve future treatments for C. diff infections.
Atlanta, GeorgiaAges 18 years+ - NCT05257538Recruiting
Stool transplant to treat early C. difficile infection
This trial tests whether giving a stool transplant (also called FMT) can treat a new, early C. difficile infection in people who have improved while on antibiotics. It may help some people prevent the infection from coming back or worsening.
TurkuAges 18–120 - NCT05739825Recruiting
Fecal transplant to change gut bacteria in C. difficile infection
This trial studies whether fecal microbiota transplantation (a procedure that transfers healthy stool bacteria) can change a person’s gut bacteria after repeated C. difficile infection. It may help reduce recurring infections by restoring a healthier balance of gut microbes.
RomaAges 18–90 - NCT06228352Recruiting
Bile acids and gut bacteria in C. difficile with ulcerative colitis
This study looks at how bile acids and gut bacteria relate to C. difficile infection in children with ulcerative colitis. It aims to find better ways to predict and treat these infections.
ParisAges Up to 17 years - NCT06370884RecruitingPhase 1
Gut bacteria transplant after colon surgery
This study tests whether transplanting healthy gut bacteria into people who have had part of their colon removed can improve recovery. It may help prevent infections or other complications after surgery.
Minneapolis, MinnesotaAges 18–75 - NCT06692179RecruitingPhase 1
Testing a freeze-dried fecal transplant during colon surgery
This trial tests if giving a special freeze-dried mixture of healthy gut bacteria right after colon surgery is safe and possible. It may help patients recover better after the procedure.
Minneapolis, MinnesotaAges 18–75 - NCT07401680RecruitingPhase 1
Stool transplant for active ulcerative colitis
This trial tests whether a stool transplant (fecal microbiota transplantation) can help manage active ulcerative colitis. You would receive a transplant from a healthy donor to see if it improves your symptoms.
Calgary, AlbertaAges 18 years+ - NCT07458984RecruitingPhase 3
Fecal transplant capsules for repeat C. diff infections
This trial tests if capsules containing fecal microbiota can prevent further Clostridioides difficile infections in people who have had at least two recurrences. If you've had multiple C. diff infections and your symptoms go away with antibiotics, this treatment might help keep them from coming back.
Helsinki, UusimaaAges 18 years+
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Clostridioides Difficile Infection trials by city
Studies with a site in or near these metro areas.
Clostridioides Difficile Infection trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for clostridioides difficile infection?
- Yes. Clin2 currently lists 24 recruiting clostridioides difficile infection studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a clostridioides difficile infection trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a clostridioides difficile infection trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.