Berberine for stomach precancerous changes
Treatments studied
Part of Digestive system clinical trials.
This trial tests whether berberine, a natural plant compound, can help reverse precancerous changes in the stomach lining. If you have a certain type of stomach cell change (called gastric intestinal metaplasia) and do not have an H. pylori infection, this study might be an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have been diagnosed with a moderate to advanced stomach precancerous condition (OLGIM stage II–IV) within the last 3 months.
- You do not currently have an H. pylori infection. If you had it and treated it successfully, you can join.
- You have not taken NSAID pain relievers (like ibuprofen or aspirin), statins for cholesterol, or metformin for diabetes regularly (at least once a week).
- You have not had any stomach surgery, including endoscopic removal of growths, or a past diagnosis of cancer.
- You are not pregnant or breastfeeding, and you do not have severe heart, kidney, or liver disease.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if ursodeoxycholic acid can reverse intestinal metaplasia (a precancerous stomach condition) in patients who have no H. pylori infection. The goal is to see if this medication can help lower the risk of stomach cancer.
This trial tests whether a treatment can reverse stomach lining changes called GIM that increase cancer risk. It's for people who have had a past H. pylori infection but no current stomach cancer, and whose GIM has certain high-risk features.
This study tests if Weifuchun tablets can reverse precancerous changes called gastric intestinal metaplasia. If you have this condition and no H. pylori infection, you may qualify.
This study collects health information from people at different stages of stomach cancer risk, including those with precancerous changes, healthy individuals, and those with early stomach cancer. The goal is to better understand and prevent stomach cancer.
This study tests whether a natural supplement called berberine changes the bacteria in your gut. You'll be compared to healthy people without polyps to see if berberine helps prevent polyps from coming back.
This trial tests whether a safe, older drug (pyrvinium) can reverse abnormal changes in the stomach lining that may lead to cancer. It might help people who have precancerous cells in their stomach to prevent them from becoming cancer.
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