Testing different strengths of numbing medicine for shoulder replacement
Treatments studied
Part of Bones, joints & muscles, Pain clinical trials.
This study compares two different strengths of local anesthetic used in a nerve block for shoulder replacement surgery. The goal is to see if one strength helps reduce pain that can come back as the block wears off.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and scheduled for a shoulder replacement.
- You do not have chronic pain conditions like fibromyalgia or complex regional pain syndrome.
- You have not used strong pain medicines (opioids) daily for the past 3 months.
- You do not have serious lung problems like COPD or untreated sleep apnea.
- Your kidney function (GFR) is 60 or higher, and you are not allergic to the numbing medicines used.
- You can follow up after surgery and do not need a special catheter or injected pain pump.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether giving a continuous nerve block (an ongoing numbing medicine near the shoulder) can reduce 'rebound pain'—the sharp increase in pain that often happens after the block wears off—following shoulder replacement surgery done as an outpatient. If you qualify, you might have better pain control and a smoother recovery at home.
This trial compares two types of numbing medications (liposomal bupivacaine and standard bupivacaine) given as a nerve block for shoulder surgery. Researchers want to see which one works better for pain relief and causes fewer problems with your breathing afterward.
This trial tests whether a longer-lasting nerve block during shoulder surgery can better manage pain and affect one-sided diaphragm (breathing muscle) weakness. It may help people having planned (first-time) shoulder surgery who are able to follow study pain-checks.
This trial compares two different ways of giving numbing medicine around the shoulder nerve before reverse shoulder replacement surgery. It may help find which method works better for pain control and comfort after surgery.
This study compares two ways to manage pain after shoulder replacement surgery: a long-acting numbing medicine (ZYNRELEF) versus a temporary nerve block catheter. It aims to see which provides better pain control and recovery.
This study compares two types of nerve blocks to see which one provides better pain relief after outpatient shoulder surgery. Participants will receive one of the two blocks, and the study will track their pain and recovery.
Hear when a new Rebound Pain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.