Clin2
NCT07152184Possibly a fitNot yet recruiting

Comparing antipsychotic dose reduction versus staying on current treatment

Patient With Schizophrenia Spectrum DisorderNLM Classification WM 203, Psychology:Schizophrenic PsychologySchizophrenia Spectrum and Other Psychotic Disorders

Part of Mental health clinical trials.

This study compares whether slowly reducing antipsychotic medication is as effective as staying on the current dose for people with schizophrenia or related disorders. It uses a personalized approach to help you and your doctor decide which option may work best for you.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
288 people
Ages
18 years to 60 years
Study type
Interventional

Who can take part

  • You are between 18 and 60 years old
  • You have a diagnosis of schizophrenia or a related psychotic disorder
  • You have been stable (without severe symptoms) for at least 6 months
  • You are currently taking antipsychotic medication by mouth (not long-acting injections or clozapine)
  • You have a caregiver (family or friend) who can support you for the study
  • You are not hospitalized in a psychiatric ward and have not had a recent psychotic episode in the last 6 months

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07343193Recruiting
Reducing antipsychotic medication: a case study

This study looks at safely reducing or stopping antipsychotic medication in adults with psychotic disorders who are stable and interested in trying. It aims to understand how to best support patients during this process.

Strasbourg
NCT06562608Recruiting· Phase 4
Reducing Anticholinergic Medications in Schizophrenia

This trial is testing whether it is safe to slowly reduce or stop anticholinergic medications (benztropine or trihexyphenidyl) in people with schizophrenia. It aims to see if stopping these drugs can help with thinking and memory without causing worsening movement problems.

Pittsburgh, Pennsylvania
NCT05839613Not yet recruiting
Personalizing antipsychotic treatment using genetics

This study looks at how a person's genes may affect how their body processes antipsychotic medications, with the goal of helping doctors choose the best medication and dose for each person. If you are changing or starting a new antipsychotic, this study might help you get more personalized treatment.

NCT06821945Recruiting· Phase 2
Olanzapine dosing study for schizophrenia

This trial tests a slower, lower-dose schedule of the drug olanzapine for people with schizophrenia. It aims to see if a gentler start is safer and works as well, especially for those who may need less medication due to other health conditions.

Daegu
NCT02640911Recruiting
Long-term study of certain antipsychines in schizophrenia

This is an observational (non-intervention) study that follows adults with schizophrenia who are taking specific “atypical” antipsychotic medicines long-term. Researchers want to learn about patients’ experiences and outcomes while on these treatments.

Shanghai, Shanghai Municipality
NCT05958875Recruiting· Phase 4
Six-week medicine switch for schizophrenia after first treatment failure

This trial tests whether a more intensive medication approach for schizophrenia (or related conditions) helps people who didn’t improve on their first tried medicine. Participants will usually switch medicines and be compared against “treatment as usual.”

Innsbruck

Hear when a new Schizophrenia Spectrum and Other Psychotic Disorders trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.