Comparing treatments after stomach cancer surgery
Treatments studied
Part of Cancer, Digestive system clinical trials.
This trial tests different adjuvant treatments for patients who had stomach or gastroesophageal junction cancer, received chemotherapy with immunotherapy before surgery, and had a complete response (no cancer left) in the surgical sample. It aims to find which treatment works best to prevent the cancer from coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have been diagnosed with stomach or gastroesophageal junction adenocarcinoma (a type of cancer)
- Your cancer does not have high levels of HER2 (a protein that can make cancer grow)
- You received at least 3 to 4 cycles of chemotherapy plus immunotherapy before surgery
- You had surgery to remove the cancer and tests showed no cancer cells left in the removed tissue
- Your doctor thinks you need more treatment after surgery
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding immunotherapy to standard chemotherapy after surgery helps prevent stomach or gastroesophageal junction cancer from coming back. It is for people who already had chemotherapy before surgery and have HER2-negative adenocarcinoma.
This trial tests whether adding a short course of radiation to a combination of immunotherapy (PD-1 inhibitor) and chemotherapy (SOX) before surgery helps treat advanced stomach or GEJ cancer. It aims to see if the extra radiation makes the treatment more effective.
This trial tests combining chemotherapy (SOX), an immunotherapy drug (tislelizumab), and low-dose radiation before surgery for people with locally advanced stomach or gastroesophageal junction cancer. The goal is to see if this combination shrinks tumors more effectively.
This trial is testing a combination of three medicines—an immunotherapy (anti-PD-1), an immune booster (thymalfasin), and a chemotherapy regimen (SOX)—given before surgery to shrink stage III stomach or gastroesophageal junction cancer and improve outcomes.
This trial tests a new immunotherapy drug (serplulimab) combined with standard chemotherapy before surgery for patients with locally advanced stomach or gastroesophageal junction cancer. The goal is to see if this combination helps shrink the tumor and improve outcomes.
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