Testing a kidney-protecting drug in sickle cell disease
Treatments studied
Part of Blood & lymphatic, Genetic & congenital, Kidney & urinary, Women’s health & pregnancy clinical trials.
This study tests whether empagliflozin, a medicine that protects the kidneys in people with diabetes, can also protect the kidneys in people with sickle cell disease. The goal is to see if it can reduce protein in the urine, which is a sign of kidney stress.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have sickle cell disease (genotypes HbSS or HbSβ0-thalassemia).
- Your urine must show a moderate amount of protein (albuminuria with UACR between 100 and 2,000 mg/g).
- Your hemoglobin level must be 5.5 g/dL or higher.
- You cannot have diabetes.
- You cannot have an active leg ulcer or a current urinary tract infection.
- You cannot have had a sickle cell crisis or other severe pain event requiring hospitalization in the last 14 days.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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