Psilocybin and Trazodone for tough-to-treat depression
Treatments studied
Part of Mental health clinical trials.
This trial tests if taking psilocybin (a psychedelic drug) with trazodone (an antidepressant) can help people whose depression hasn't improved with at least two standard antidepressants. If you have treatment-resistant depression, this study might be an option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have depression without psychosis or hallucinations.
- At least two different antidepressants haven't worked for you.
- Your depression is moderate to severe (score of 20 or higher on a depression scale).
- You are not currently taking certain medications like lithium, antipsychotics, or opioids.
- You don't have a history of bipolar disorder, schizophrenia, or other major mental health conditions.
- You haven't used psychedelics in your current depressive episode.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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