Testing Ambros Therapy for Early CRPS
Part of Brain & nervous system, Pain clinical trials.
This trial tests if an intravenous medicine called AMBTX-01 (neridronate) can help people with early-stage Complex Regional Pain Syndrome (CRPS) type 1. It focuses on those whose affected limb feels warm, looks red, and is swollen.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old.
- You have been diagnosed with CRPS type 1 in one arm or leg (not both) within the last 6 months.
- Your affected limb is warm, swollen, and looks redder than the other limb.
- You have not used certain bone medications (like bisphosphonates) or ketamine in the past 6 to 12 months.
- You are not pregnant, breastfeeding, or planning to become pregnant during the study.
- You do not have severe kidney problems, low calcium, low vitamin D, or active dental issues.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study gives an extended course of neridronate infusions to people who completed the earlier AMBTX-01-301 trial, to see if longer treatment safely keeps easing their chronic pain and other symptoms of complex regional pain syndrome (a long-lasting pain condition, often after an injury).
This trial tests a gentle nerve-stimulation treatment applied to the ear, added to standard physical therapy for people with CRPS in the hand. It may help reduce pain and improve hand function.
This trial tests whether a low dose of naltrexone, a medication that may help calm overactive immune and pain signals, can reduce pain and improve daily life in people with complex regional pain syndrome (CRPS), a chronic condition that often causes severe pain and swelling.
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This trial compares two hand therapy techniques — contrast baths (alternating warm and cool water) and compression with whirlpool therapy — to see which better eases early-stage complex regional pain syndrome (CRPS) after a hand or wrist injury. If you've had hand or wrist trauma and are still in pain, this study might help you find a treatment that reduces discomfort and improves hand use.
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