Clin2
NCT07857733Possibly a fitNot yet recruiting

Extended treatment study for complex regional pain syndrome

Complex Regional Pain Syndrome Type I

Part of Brain & nervous system, Pain clinical trials.

This study gives an extended course of neridronate infusions to people who completed the earlier AMBTX-01-301 trial, to see if longer treatment safely keeps easing their chronic pain and other symptoms of complex regional pain syndrome (a long-lasting pain condition, often after an injury).

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
135 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You took part in the earlier neridronate study and finished the 12-week check.
  • You have ongoing moderate-to-severe pain or other CRPS symptoms that need more treatment.
  • You are willing to receive 4 more infusions through a vein and have follow-up safety tests.
  • Your kidney function must be good, and you must not have had certain other bone or pain treatments recently.
  • If you can become pregnant, you must use effective birth control during treatment and for 6 months after.
  • You must be able to give informed consent and follow the study schedule.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07210515Recruiting· Phase 3
Testing Ambros Therapy for Early CRPS

This trial tests if an intravenous medicine called AMBTX-01 (neridronate) can help people with early-stage Complex Regional Pain Syndrome (CRPS) type 1. It focuses on those whose affected limb feels warm, looks red, and is swollen.

Phoenix, Arizona
NCT06306157Enrolling by invitation· Phase 4
Low dose naltrexone for complex regional pain syndrome

This trial tests whether a low dose of naltrexone, a medication that may help calm overactive immune and pain signals, can reduce pain and improve daily life in people with complex regional pain syndrome (CRPS), a chronic condition that often causes severe pain and swelling.

New York, New York
NCT07811362Recruiting
Tracking long-term outcomes for CRPS after neridronate treatment

This study is a registry that tracks people with Complex Regional Pain Syndrome (CRPS) who already received neridronate infusions in a previous trial. It looks at how they do over the long term to learn more about the treatment's lasting effects.

Durham, North Carolina
NCT07208825Recruiting
Conservative care for complex regional pain syndrome

This study tests whether a conservative treatment plan can help people with complex regional pain syndrome (CRPS), a condition where pain lasts longer than expected after an injury. You may qualify if you have had CRPS symptoms for up to 5 years and are between ages 18 and 70.

Oulu, North Ostrobothnia
NCT02502162Recruiting
Low-dose naltrexone for complex regional pain syndrome

This trial tests whether low-dose naltrexone can reduce symptoms of complex regional pain syndrome (CRPS), a long-lasting pain condition in an arm or leg. It may help by targeting pain signaling, but you must meet specific CRPS diagnosis and medication rules to join.

Palo Alto, California
NCT06393101Recruiting· Phase 1
High-CBD cannabis extract for complex regional pain syndrome treatment

This study tests a high-CBD cannabis extract (BRC-002) to see if it can help reduce pain and improve health in people with Complex Regional Pain Syndrome (CRPS). Participants will not use opioids or other cannabis during the study.

La Jolla, California

Hear when a new Complex Regional Pain Syndrome Type I trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.