Study of a new drug for GRIN-related developmental disorder
Part of Brain & nervous system, Genetic & congenital clinical trials.
This trial tests a new drug for children with GRIN-related neurodevelopmental disorder caused by certain gene changes. The drug aims to improve seizures and other symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Diagnosed with GRIN-NDD due to a specific GRIN gene change that makes the NMDA receptor overactive
- For one group: have at least 4 seizures per week that affect awareness and have not been controlled by at least 2 seizure medicines
- For the other group: have significant developmental symptoms and a severity score of 4 or higher
- Be on a stable dose of seizure medicines for at least 4 weeks before the study starts
- Weigh at least 5 kg (11 pounds)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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