Brain tissue study of synaptic loss in mental and brain diseases
Part of Brain & nervous system, Mental health clinical trials.
This study looks at how brain connections break down in people with psychiatric disorders (like schizophrenia, depression, or bipolar disorder) or neurodegenerative diseases (like Alzheimer's or frontotemporal dementia). It uses donated brain tissue after death to understand why symptoms occur.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (or the donor) had a diagnosis of paranoid schizophrenia, major depression, or bipolar disorder, or Alzheimer's disease or frontotemporal dementia.
- For psychiatric disorders: donor was older than 40 at death. For neurodegenerative diseases: donor was older than 50 at death.
- The postmortem delay (time from death to tissue processing) was less than 24 hours.
- For schizophrenia: no other neurological or psychiatric conditions, and no history of substance use disorder.
- The diagnosis was confirmed by a psychiatrist or by neuropathology (brain tissue analysis).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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