Clin2
NCT07238569Possibly a fitNot yet recruiting

EBV-guided immunotherapy for advanced nasopharyngeal cancer

Nasopharyngeal Cancinoma (NPC)Nasopharangeal Cancer

Treatments studied

Part of Cancer, Ear, nose & throat clinical trials.

This trial tests whether giving an immunotherapy drug called adebrelimab, based on levels of EBV DNA in the blood, can help people with advanced nasopharyngeal cancer. It is for those who have finished initial chemotherapy and still have signs of the virus or stable disease.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
516 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You are between 18 and 65 years old.
  • You have a type of nasopharyngeal cancer called non-keratinizing (confirmed by biopsy).
  • You are physically active and able to care for yourself (ECOG score 0-1).
  • Your cancer is stage II or III (but not T3N0-1).
  • You have completed 3 cycles of induction chemotherapy (gemcitabine, cisplatin, and adebrelimab) and still have EBV DNA in your blood or your disease has not progressed.
  • You have adequate blood, liver, and kidney function, and no serious heart, lung, or autoimmune conditions.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06802835Recruiting· Phase 1/Phase 2
EGFR antibody plus immunotherapy and chemo for advanced nasopharyngeal cancer

This trial tests a combination of an EGFR antibody, a PD-1 inhibitor, and chemotherapy for people with nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this new mix can help shrink tumors or slow the disease.

Guangzhou, Guangdong
NCT07373990Not yet recruiting· Phase 3
Immunotherapy plus chemoradiotherapy for advanced nasopharyngeal cancer

This trial tests a new combination of an immunotherapy drug (tislelizumab) plus standard chemoradiotherapy for people with advanced nasopharyngeal carcinoma. It aims to find out if this combination is more effective than standard care alone.

NCT07138989Not yet recruiting· Phase 2
Epstein-Barr virus reactivation plus immunotherapy for recurrent nasopharyngeal cancer

This trial tests a combination of a drug that reactivates the Epstein-Barr virus (EBV) in the body plus an immunotherapy drug (PD-1 antibody) for people with nasopharyngeal cancer that has returned or spread. The goal is to see if this combination can help the immune system fight the cancer more effectively.

Guangzhou, Guangdong
NCT07154069Recruiting· Phase 3
Immunotherapy for advanced nasopharyngeal cancer after chemo

This trial tests if adding an immunotherapy drug (PD-1 inhibitor) after standard induction chemotherapy helps keep advanced nasopharyngeal cancer from coming back. It is for people who have completed 3 cycles of GP chemotherapy combined with a PD-1 inhibitor and have not had their cancer progress.

Guangzhou, Guangdong
NCT07067268Recruiting· Phase 2
Tislelizumab and capecitabine for nasopharyngeal cancer with remaining EBV DNA

This trial tests a combination of two drugs, tislelizumab and capecitabine, for people with nasopharyngeal cancer who still have detectable EBV DNA in their blood after finishing radiation therapy. The goal is to see if this treatment can help clear the virus and improve outcomes.

Shanghai, China
NCT07110558Not yet recruiting· Phase 2
Radiation and immune therapy for advanced nasopharyngeal cancer

This trial tests a new treatment for nasopharyngeal cancer that adds an immune-boosting drug (toripalimab) before and after radiation therapy, while skipping radiation to the neck lymph nodes. It aims to see if this approach is effective and reduces side effects.

Guangzhou, Guangdong

Hear when a new Nasopharyngeal Cancinoma (NPC) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.