New drug combo for KRAS G12D pancreatic cancer
Part of Cancer, Digestive system clinical trials.
This trial tests a new targeted drug (HRS-4642) combined with another drug (Nimotuzumab) and two chemotherapy drugs for people with a specific type of pancreatic cancer that has a KRAS G12D mutation. The goal is to see if this combination can help make the tumor smaller and possibly removable by surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- Your pancreatic cancer has a specific gene change called KRAS G12D.
- Your cancer is borderline resectable—it cannot be removed by surgery right away but might be after treatment.
- You have not had any previous chemotherapy or other systemic treatment for your cancer.
- You are in good general health (able to take care of yourself and do light work).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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