Testing a new RAS inhibitor for advanced solid tumors
Part of Cancer clinical trials.
This trial is testing a new oral medication (AN9025) for people with advanced solid tumors that have a RAS mutation, such as pancreatic, colorectal, lung, or melanoma. It aims to see if the drug can shrink tumors or slow their growth when other treatments have stopped working.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 or older
- Your cancer must have a RAS mutation (KRAS, NRAS, or HRAS) confirmed by a lab test
- Your cancer has spread or is advanced, and standard treatments no longer work
- You are in generally good health (able to take care of yourself, with good kidney, liver, and heart function)
- You have not had a prior treatment that targets the same type of RAS pathway
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This trial tests a new drug, AN4035, for people with advanced cancers that have certain RAS gene mutations and high levels of a protein called CEACAM5. The goal is to see if AN4035 can help when other treatments have stopped working or aren't an option.
This phase 1 trial tests an oral drug called PAS-004 for people with advanced solid tumors that have certain gene changes. It aims to find a safe dose and see if the drug can stop tumor growth.
This early-stage trial tests BLU-924, a new drug designed to target cancer cells with specific KRAS mutations (a common genetic change in pancreatic, lung, and colon cancers). The study aims to find the right dose and see how well it works in patients whose cancers have progressed despite standard treatments.
This trial tests whether RMC-6236 can treat advanced solid tumors that have specific RAS-related gene changes (especially certain KRAS G12 mutations). You may be able to join if your tumor’s DNA test shows the right mutation and your overall health is good enough for study visits.
This trial tests an experimental oral drug called ERAS-0015 for people with advanced solid tumors that have certain genetic changes (RAS mutations). It may be an option if you have no standard treatments left or cannot take them.
This trial tests new drugs that target specific RAS mutations in advanced gastrointestinal cancers, like pancreatic or colorectal cancer. It aims to see if these drugs can shrink tumors or slow their growth.
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