Malaria infection study in Thai adults using mosquito bites
Part of Infections clinical trials.
This study will expose healthy adults to a small number of mosquito bites carrying the P. vivax malaria parasite to learn how many bites are needed to cause infection. Participants will be closely monitored and treated in the hospital to ensure safety.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 20 and 55 years old.
- You weigh more than 50 kg.
- You have never had malaria before.
- Your blood cells have a specific marker (Duffy antigen) that the parasite needs to enter.
- Your body processes certain medicines normally (CYP2D6 enzyme).
- You have a normal level of an enzyme called G6PD (tested before the study).
- If you are a woman, you must use effective birth control during the study and for 3 months after.
- You agree not to donate blood during the study and for 1 year after.
- You are willing to take anti-malaria medicine to cure the infection after the study.
- You must stay in a hospital in Bangkok for monitoring until treatment is finished and symptoms go away.
- You are willing to live in Bangkok during the main part of the study and be followed for 1 year after treatment.
- You can be reached by mobile phone 24/7 during the study period.
- You can read and write in Thai and understand all the study information.
- Your heart risk is low (less than 10% over 10 years per Thai guidelines).
- You have at least a bachelor's degree.
- You have no medical conditions that would make the study unsafe (e.g., severe heart, kidney, or liver disease).
- You are not pregnant, breastfeeding, or planning pregnancy within 1 year after the study.
- You do not have certain blood disorders like thalassemia or sickle cell disease.
- You do not have hepatitis B, hepatitis C, HIV, syphilis, or HTLV infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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