Organ preservation treatment for very low rectal cancer
Treatments studied
Part of Cancer, Digestive system clinical trials.
This Phase 2 trial tests a “total neoadjuvant” treatment plan (medicine given before surgery) that may help some people avoid or reduce surgery for very low rectal cancer. It aims to improve the chance of keeping more normal function while still treating the cancer safely.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- Your rectal cancer has been confirmed by biopsy, and it is staged as cT3-4N0 or cT1-4N1-2, and the tumor is very close to the anus (within 2 cm).
- No prior chemotherapy, immunotherapy, or radiotherapy for rectal cancer, and you have not had pelvic radiation before.
- Your general health is good enough for treatment: ECOG 0–2 and ASA I–III, and recent blood tests show adequate white blood cells, platelets, liver tests, and kidney function.
- Your heart and other major medical issues must be stable (no recent severe heart failure or angina, no uncontrolled infection or serious uncontrolled illness), and you are able to follow the study plan.
- You can use effective birth control (and you must not be pregnant or breastfeeding), and you must sign the informed consent form.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether people with early- to intermediate-stage low rectal cancer can avoid surgery if their tumor responds well to a full course of chemotherapy and radiation. It starts with brief chemotherapy, then adjusts treatment based on how much the tumor shrinks.
This trial tests a program that helps you and your doctor decide together whether to avoid surgery and keep your rectum after chemo and radiation. It's for people with early-stage rectal cancer who have not had prior treatment for this cancer.
This trial tests whether a full course of chemotherapy and radiation before any surgery (called total neoadjuvant therapy) can help you avoid surgery and preserve your rectum. It is for people with a specific early stage of rectal cancer that has not spread.
This Phase 2 study tests a “total neoadjuvant” (chemo plus radiation before the main treatment) plan to see if some people with low rectal cancer can keep their anus. It may help you avoid permanent colostomy if your cancer responds well and you meet the study rules.
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