Total treatment with chemotherapy and short radiation before surgery
Part of Cancer, Digestive system clinical trials.
This trial tests whether combining chemotherapy (mFOLFOX6) and a short course of radiation before surgery improves outcomes for people with resectable rectal cancer. The goal is to shrink and control the cancer early and then remove it with curative surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Rectal cancer confirmed from a biopsy as adenocarcinoma, diagnosed within 90 days
- Cancer is likely curable by surgery and has not spread to distant organs (not M1)
- Tumor stage is T3–4 with node involvement (N0, N1, or N2 as specified) and no distant spread
- You can have the planned chemo and radiation timeline and have ECOG 0–2 (not very limited day-to-day)
- Blood counts, liver, and kidney tests are at safe levels for chemotherapy (with specific minimums)
- You must be able to sign consent, and if you can become pregnant, you must have a negative pregnancy test and use birth control during treatment and 3 months after
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of chemotherapy and radiation therapy before surgery for people with mid or low rectal cancer that hasn't spread. The goal is to see if this approach works better than current treatments.
This trial compares different combinations of chemotherapy drugs given before surgery to the standard approach of chemoradiation (chemotherapy plus radiation) for rectal cancer that has not spread. The goal is to see if the drug combinations are more effective at shrinking tumors and improving outcomes.
This trial tests whether giving chemotherapy and an immunotherapy drug before surgery can help shrink rectal cancer tumors and improve outcomes. It is for patients whose tumors are not caused by a specific genetic mismatch repair problem.
This trial tests a new treatment sequence for locally advanced rectal cancer: a short course of radiation followed by a combination of immunotherapy (cadonilimab) and chemotherapy (mFOLFOX6) before surgery. The goal is to shrink the tumor more effectively and potentially improve outcomes.
This trial tests a combination of chemotherapy plus two newer medicines (suvemcitug and enlonstobart) before surgery for middle rectal cancer. The goal is to shrink the tumor and avoid radiation therapy, which may spare some side effects.
This Phase 3 trial compares two treatment plans given before rectal surgery. It tests whether stronger chemotherapy alone works better than chemotherapy pills plus long-term radiation to improve outcomes for locally advanced rectal cancer.
Hear when a new Rectal Cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.