Treatments for a chronic cough that doesn't get better
Treatments studied
Part of Lungs & breathing clinical trials.
This study tests two treatments for a chronic cough that doesn't get better with usual care. You may receive a medication that affects the nerves (a neuromodulator), a cough control therapy (special exercises and education), both, or neither. The goal is to see which approach helps reduce coughing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a cough that has lasted more than 8 weeks.
- Your cough is either unexplained (after normal tests) or is due to a condition like asthma, allergies, or acid reflux, but treatment for that condition did not stop the cough.
- You have not already tried low-dose morphine, pregabalin, or cough control therapy for your cough.
- You are not currently taking morphine, pregabalin, gabapentin, amitriptyline, or dextromethorphan, or you can safely stop them at least 2 weeks before the study starts.
- You are not a current smoker, and if you are an ex-smoker, you quit more than 6 months ago or your smoking history is less than 20 pack-years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study tests whether two doses of duloxetine and amitriptyline can reduce symptoms in people with chronic cough that hasn’t responded to usual care. You may join to see if these medicines lessen cough severity over an 8-week blinded treatment period.
This trial tests whether an extended-release medication called nalbuphine can reduce coughing in people with chronic cough that hasn't improved with other treatments. You may be eligible if you've had a persistent cough for at least a year and have already tried treatments for conditions that could cause it.
This study tests a behavior-based therapy to help you gain control over a persistent cough that hasn't responded to other treatments. You will learn techniques to reduce coughing during a 4-week program.
This study tests an investigational drug called HW091077 for people with chronic cough that doesn't improve with usual treatments or has no clear cause. The drug targets a protein involved in the cough reflex and may help reduce coughing.
This trial tests a behavioral therapy for people whose chronic cough (lasting more than 8 weeks) hasn't improved with usual treatments like asthma or reflux medicine. You may join if your cough is triggered by things like talking, laughing, cold air, or irritants, and you have throat symptoms like irritation or hoarseness.
This 24-week study tests whether a new medicine called BLU-5937 can help adults whose chronic cough hasn't improved with standard treatments. Chronic cough that lasts a year or longer can seriously affect quality of life, and this trial explores whether this drug might provide relief.
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