Testing nalbuphine extended-release for chronic cough
Treatments studied
Part of Lungs & breathing clinical trials.
This trial tests whether an extended-release medication called nalbuphine can reduce coughing in people with chronic cough that hasn't improved with other treatments. You may be eligible if you've had a persistent cough for at least a year and have already tried treatments for conditions that could cause it.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a chronic cough that has lasted at least one year.
- Standard treatments for cough-related conditions have not helped enough, or no cause has been found after testing.
- You have had a chest X-ray or CT scan in the last two years showing no major lung issues causing the cough.
- Your cough frequency is at least 10 times per hour over 24 hours, measured by a special recording device.
- Your lung function test (spirometry) shows a specific ratio (FEV1/FVC ≥ 60%) that indicates no significant blockage.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This 24-week study tests whether a new medicine called BLU-5937 can help adults whose chronic cough hasn't improved with standard treatments. Chronic cough that lasts a year or longer can seriously affect quality of life, and this trial explores whether this drug might provide relief.
This study tests two treatments—nerve blockers and a cough control therapy—for people with chronic cough that hasn't improved with standard treatments or has no clear cause. The goal is to find better ways to reduce coughing and improve quality of life.
This Phase 2 study tests whether two doses of duloxetine and amitriptyline can reduce symptoms in people with chronic cough that hasn’t responded to usual care. You may join to see if these medicines lessen cough severity over an 8-week blinded treatment period.
This trial tests a new medicine, HW091077, for people who have had a chronic cough for at least a year that hasn't gotten better with treatment or has no clear cause. It aims to see if the drug can help reduce coughing.
This study tests a behavior-based therapy to help you gain control over a persistent cough that hasn't responded to other treatments. You will learn techniques to reduce coughing during a 4-week program.
This study tests a behavioral therapy delivered through group video calls to help people with a chronic dry cough that has no clear cause. It may offer a non-drug way to reduce coughing.
Hear when a new Refractory Chronic Cough trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.