Testing two doses of two nerve pain medicines for chronic cough
Treatments studied
Part of Digestive system, Immune system & allergy, Lungs & breathing clinical trials.
This Phase 2 study tests whether two doses of duloxetine and amitriptyline can reduce symptoms in people with chronic cough that hasn’t responded to usual care. You may join to see if these medicines lessen cough severity over an 8-week blinded treatment period.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have had refractory (hard-to-treat) or unexplained chronic cough for at least 1 year
- Your latest chest X-ray or CT scan (within 1 year) does not show another clear cause of the cough
- Your cough severity score is at least 40 mm on a cough severity scale at screening
- You must be able to use required birth control during the study (or confirm you are not able to become pregnant)
- You must be a non-smoker now, and if you used to smoke, you must have stopped at least 12 months ago
- You must not be taking certain cough-related or antidepressant-type medicines around the study start date
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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