Salvage radiation with hormone therapy for prostate cancer recurrence
Treatments studied
Part of Cancer, Kidney & urinary clinical trials.
This trial tests how well salvage radiation therapy works for prostate cancer that has come back after surgery. It looks at whether adding hormone therapy based on PSA response improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You had your prostate removed at least 4 months ago for prostate cancer.
- Your PSA is 0.05 ng/mL or higher after surgery.
- No signs that the cancer has spread outside the pelvic area.
- If you've had hormone therapy before, it was for less than 3 months (or anti-androgen therapy for less than 30 days).
- You have not had radiation therapy to the pelvis before.
- You are able to get an imaging scan (like a PET scan) as part of the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether adding a new oral hormone blocker (rezvilutamide) to standard salvage radiation and hormone therapy can better control prostate cancer that has come back (rising PSA) after surgery.
This study tests an “early salvage” approach using radiotherapy after prostate cancer surgery when PSA starts rising again. It aims to see whether earlier treatment (chosen based on higher-risk features) can improve outcomes for people who did not take immediate extra therapy after surgery.
This trial uses a special scan (PSMA-PET) to find where prostate cancer has returned after surgery. Then doctors give a lower dose of radiation only to that area, which may reduce side effects. It is for men whose PSA level is rising after prostate removal.
This trial compares two lengths of hormone treatment (androgen deprivation therapy) given around “salvage” radiation after prostate surgery for rising PSA. It aims to see which schedule works best to control prostate cancer while keeping side effects manageable.
This trial compares two different radiation schedules to treat prostate cancer that returned based on rising PSA blood tests after prostatectomy (prostate removal). If you qualify, it may help you and your team choose a radiation approach with the goal of controlling PSA relapse.
This trial compares two schedules of pelvic radiotherapy for men whose prostate cancer has returned after surgery. Both schedules aim to control the cancer with fewer visits for one of them.
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