Testing a drug to reduce freezing of gait in Parkinson's
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether atomoxetine, a drug that boosts a brain chemical called noradrenaline, can help reduce freezing of gait—a feeling of your feet being stuck to the ground—in people with Parkinson's disease. You would continue your usual Parkinson's medications during the study and undergo walking tests and brain scans to see if the drug helps.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have been diagnosed with Parkinson's disease by a neurologist
- You experience freezing of gait (feeling like your feet are stuck) every day
- You can walk about 33 feet (10 meters) without help when your Parkinson's medication is working
- You are willing to have MRI brain scans (no metal implants, pacemaker, or severe claustrophobia)
- You are not taking certain medications like some antidepressants, strong asthma inhalers, or drugs that affect the noradrenaline system
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study uses brain imaging to understand why some people with Parkinson's suddenly feel like their feet are glued to the floor (freezing of gait). It may help find better treatments for this symptom.
This trial tests a noninvasive ultrasound treatment targeting a brain area called the pedunculopontine nucleus to help reduce freezing of gait (a sudden inability to walk) in Parkinson's disease. If you have Parkinson's and experience freezing, you may be eligible to try this new approach.
This study tests a new type of deep brain stimulation (DBS) targeting a specific brain area to help people with Parkinson's disease who have severe freezing of gait that doesn't improve with medication. It aims to see if this treatment can reduce freezing episodes and improve walking.
This study tests whether a 6-week exercise program can help people with Parkinson's disease who experience freezing of gait. You would exercise three times a week to see if it reduces freezing and improves turning.
This study looks at how a special brain pacemaker (called the Medtronic Percept device) affects walking problems like freezing of gait in people with Parkinson's. It aims to help understand and improve treatment.
This trial tests whether increasing the dose of levodopa or adjusting deep brain stimulation (DBS) can help reduce freezing of gait in people with Parkinson's who already have good control of other symptoms. It aims to find the best way to manage this common and frustrating problem.
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