Probenecid for reducing seizure clusters during hospital epilepsy monitoring
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether a drug called probenecid can help reduce the number of seizures that happen in a cluster during a hospital stay when your seizure medications are being reduced to record your seizures. The goal is to see if giving probenecid can make the monitoring period safer and more effective for people with focal epilepsy being evaluated for surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 6 and 50 years old and weigh more than 20 kg (44 lbs) for children.
- You have focal epilepsy (seizures start in one part of the brain) and are planning to have a video-EEG monitoring stay in the hospital to evaluate for epilepsy surgery.
- Your doctor plans to reduce or stop your anti-seizure medications to trigger seizures, or you are expected to have seizures naturally without reduction.
- You can take oral medications and are generally healthy.
- You do not have serious kidney problems, kidney stones, gout, or a known allergy to probenecid.
- You are not taking aspirin, methotrexate, or other medications that could interact with probenecid (though some may be allowed with caution).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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