Clinical trials
Focal Epilepsy clinical trials
Below are recruiting focal epilepsy clinical trials, each written for real people, not researchers. We’re tracking 50 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07594119RecruitingPhase 3
Testing RAP-219 to reduce seizures in focal epilepsy
This study tests a new medication called RAP-219 to see if it can reduce seizure frequency in adults with focal epilepsy (seizures starting in one area of the brain). You'll take the medication alongside your current seizure drugs and track your seizures daily using an app.
Huntsville, AlabamaAges 18–75 - NCT06210022Recruiting
Cognitive problems in drug-resistant vs drug-responsive epilepsy
This study compares thinking skills in people with focal epilepsy that responds well to medication versus epilepsy that doesn't. It aims to understand how different types of epilepsy affect memory, attention, and other cognitive functions.
MilanAges 18–60 - NCT07823465Enrolling by invitation
Brain device study for teens with focal epilepsy
This study looks at how well an implanted brain device works for teenagers with focal epilepsy that doesn't improve with medicine. The device sends small electrical pulses to specific brain areas to reduce seizures, and this study will help learn if it's safe and helpful for teens.
Waltham, MassachusettsAges 13–19 - NCT07563881RecruitingPhase 3
Testing RAP-219 for Focal Seizure Control in Adults
This study tests whether a new medication called RAP-219 can help adults with focal seizures (seizures that start in one area of the brain) control their seizures better. You would take this medication alongside your current seizure drugs for about 12 weeks.
Palmdale, CaliforniaAges 18–75 - NCT07219407RecruitingPhase 2
Long-term safety study of RAP-219 for focal seizures
This study tests the long-term safety and effectiveness of RAP-219, an investigative medication for focal epilepsy. It is for people who already completed an earlier study of RAP-219, have a type of epilepsy that doesn't respond to standard medicines, and use a surgically implanted brain device (RNS system) to help manage seizures.
Boise, IdahoAges 18–70 - NCT07193277RecruitingPhase 4
Butylphthalide for thinking problems in older adults with epilepsy
This study tests whether a medicine called butylphthalide can help improve memory and thinking in older adults with focal epilepsy who already have mild cognitive issues. It aims to find a new way to support brain health in people with epilepsy.
Wenzhou, ZhejiangAges 60–85 - NCT06612775RecruitingPhase 2
Testing CB03-154 for adults with focal epilepsy
This trial tests a new medication, CB03-154, to see if it is safe and can reduce seizures in adults with focal epilepsy. You may be able to join if you have had focal epilepsy for at least 2 years and are on a stable dose of 1 to 3 anti-seizure medications.
Melbourne, VictoriaAges 18–70 - NCT05794295Recruiting
Sleep study in people with focal epilepsy
This trial studies how sleep patterns relate to thinking and memory in people with focal epilepsy. It may help researchers understand what sleep changes could support brain function in epilepsy.
Sacramento, CaliforniaAges 18–40 - NCT07580183Recruiting
Memory and Brain Function in Epilepsy Surgery
This study examines how the brain recognizes spatial scenes (like rooms or landscapes) in people with epilepsy who may have surgery. Researchers want to understand memory patterns before and after surgery to help predict outcomes.
Sacramento, CaliforniaAges 18–55 - NCT07318870RecruitingPhase 2
Probenecid for reducing seizure clusters during hospital epilepsy monitoring
This trial tests whether a drug called probenecid can help reduce the number of seizures that happen in a cluster during a hospital stay when your seizure medications are being reduced to record your seizures. The goal is to see if giving probenecid can make the monitoring period safer and more effective for people with focal epilepsy being evaluated for surgery.
ParisAges 6–50 - NCT05673915Recruiting
Brain stimulation study for hard-to-control epilepsy
This trial tests whether noninvasive brain stimulation (using gentle electrical current through the scalp) can reduce seizures in people with epilepsy that has not responded to at least two anti-seizure medicines. If you qualify, you’d also be asked to keep track of seizures in a diary during the study.
Rochester, MinnesotaAges 6 years+ - NCT06053671Recruiting
Understanding genetics in focal epilepsy brain tissue
This study is looking at brain tissue from people with a specific type of epilepsy (Focal Cortical Dysplasia Type II). The goal is to understand what causes the seizures and how they develop, which may help improve future treatments.
LondonAges Any age - NCT07680842Recruiting
Non-invasive ultrasound for drug-resistant epilepsy
This study tests a non-invasive focused ultrasound treatment for people with epilepsy that doesn't respond to medications. The goal is to see if this gentle ultrasound can reduce seizures without surgery.
San Francisco, CaliforniaAges 21–65 - NCT02890641Recruiting
Study of brain signals and genes in hard-to-treat epilepsy
This study looks at genetic factors and brain electrical activity in children whose seizures are difficult to control with standard medicines. It also involves exams like MRI and possibly procedures under anesthesia, to better understand seizure causes and help future care.
ParisAges 3 months–25 years - NCT06855901Recruiting
Home EEG monitoring for rare epilepsy
This study tests using a small, home-based EEG device to monitor brain activity over several weeks in people with hard-to-control seizures, rare epilepsies, or developmental and epileptic encephalopathies. The goal is to see if this method can better track seizures and improve care.
Roma, ItalyAges 12 years+ - NCT06388707RecruitingPhase 1/Phase 2
Ultrasound therapy for drug-resistant temporal lobe epilepsy
This study tests if a new, non-invasive ultrasound treatment can safely reduce seizures in people whose seizures start in the temporal lobe and have not been controlled by at least two anti-epileptic drugs. The ultrasound is delivered through the scalp to gently stimulate the brain area where the seizures begin.
Palo Alto, CaliforniaAges 18 years+ - NCT03644732Recruiting
Study of brain activity during epilepsy testing using SEEG
This study maps how thinking and memory work by recording brain signals during a presurgical epilepsy workup. It may help doctors better understand drug-resistant focal epilepsy and improve how they plan treatment.
GrenobleAges 18–65 - NCT07238868RecruitingPhase 2
Long-term safety study of CB03-154 for epilepsy
This study is a long-term follow-up for people with epilepsy who already completed a previous trial of the drug CB03-154. It checks if the drug remains safe and effective over more time.
Melbourne, VictoriaAges 18–70 - NCT05718817Enrolling by invitationPhase 3
Long-term study of XEN1101 for people with epilepsy
This study gives XEN1101 in an open-label way (everyone knows they’re getting the drug) to people who finished earlier epilepsy studies. It aims to see how the treatment continues to work and whether it’s safe over the long term.
Phoenix, ArizonaAges 12 years+ - NCT06794606Recruiting
Study for drug-resistant focal epilepsy
This trial looks at ways to diagnose and treat focal epilepsy that isn't controlled by medications. It includes patients with or without a visible brain lesion on imaging.
MilanAges 18 years+ - NCT06792383Recruiting
Psychological and psychiatric assessment before epilepsy surgery
This study evaluates psychological and psychiatric well-being in adults with drug-resistant epilepsy who are being considered for surgery. It aims to understand factors that may affect outcomes and patient experience.
MilanAges 18 years+ - NCT06550726Recruiting
Advanced MRI for hard-to-control focal epilepsy
This study tests a new, very detailed type of MRI to find the exact spot in the brain where seizures start in people with hard-to-control focal epilepsy. If you have epilepsy that hasn't been helped by medications and previous MRIs didn't find a cause, this scan might give more answers.
Hong KongAges Any age - NCT03865771Recruiting
Sleep study to improve memory in children with focal epilepsy
This study looks at how sleep affects memory in children with certain types of age-related focal epilepsy. It compares them to children hospitalized for non-nerve (non-neurologic) reasons to see whether sleep-related brain patterns relate to learning and memory.
NancyAges 6–13 - NCT06271785Recruiting
Predicting success of epilepsy surgery in children
This study uses a special, detailed brain-mapping technique (called high-resolution electrical source imaging) to see how well it can predict success after epilepsy surgery in children. It aims to help doctors decide which children might benefit most from surgery.
AngersAges 2–17
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Focal Epilepsy trials by city
Studies with a site in or near these metro areas.
Focal Epilepsy trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for focal epilepsy?
- Yes. Clin2 currently lists 50 recruiting focal epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a focal epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a focal epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.