Glofitamab and CAR-T therapy for large b-cell lymphoma
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial combines two treatments for large b-cell lymphoma that has come back or not responded to previous therapy. Glofitamab is a drug that helps the immune system attack cancer cells, and CAR-T therapy uses your own white blood cells, which are modified in a lab to find and kill cancer cells. This study aims to see if the two treatments together are safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your lymphoma must be a type that tests positive for CD19 and CD20 markers.
- You have had at least one prior treatment (like chemotherapy or antibody therapy) and your cancer has returned or not responded.
- You must have at least one high-risk feature, such as lymphoma outside the lymph nodes, a tumor larger than 4 cm, or a TP53 gene mutation.
- Your cancer has not spread to the brain or spinal cord.
- You are able to care for yourself (ECOG performance status 0-2) and are expected to live at least 3 months.
- Your heart, lungs, liver, kidneys, and blood counts are working well enough to participate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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