Clin2
NCT07599423Possibly a fitNot yet recruiting

Glofitamab plus chemotherapy for relapsed large b-cell lymphoma

Diffuse Large B Cell Lymphoma (DLBCL)

Treatments studied

Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.

This trial tests a new combination of drugs (glofitamab plus GemOx) against the usual treatment for people whose diffuse large B-cell lymphoma (a type of blood cancer) has returned or not gone away after initial therapy. The goal is to see if this new approach works better and helps you live longer.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
96 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • Must be 18 years or older
  • Must have diffuse large B-cell lymphoma that came back or didn't improve after one prior treatment
  • Must have at least one measurable tumor on a CT scan
  • Must have adequate kidney and liver function and blood counts
  • Must be able to perform daily activities with minimal assistance (ECOG 0 or 1)
  • Cannot have had more than one prior treatment for this lymphoma

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06656234Not yet recruiting
Glofitamab for relapsed or refractory large B-cell lymphoma

This study looks at how well a new drug called glofitamab works in real life for people with a type of lymphoma that has come back or not improved after treatment. It aims to see if the drug is safe and effective outside of a clinical trial setting.

Shanghai, Shanghai Municipality
NCT06765317Recruiting· Phase 2
Glofitamab therapy for older adults with diffuse large B-cell lymphoma

This trial tests a new combination therapy using glofitamab for people aged 65 or older with diffuse large B-cell lymphoma who have not received prior treatment. The goal is to see if this approach is safe and effective for patients who are considered too frail for standard therapies.

Basking Ridge, New Jersey
NCT06050694Recruiting· Phase 2
Testing glofitamab plus chemo for untreated DLBCL

This trial tests a new drug called glofitamab combined with standard Pola-R-CHP chemotherapy for people with untreated DLBCL. The goal is to see if using PET scans and blood tests early on can guide treatment and improve outcomes.

Toronto, Ontario
NCT07774234Not yet recruiting· Phase 2
A combination of four drugs for relapsed large b-cell lymphoma

This study tests a new combination of four drugs—sonrotoclax, glofitamab, gemcitabine, and oxaliplatin—in people with large B-cell lymphoma that has come back or not responded to earlier treatment. The goal is to see if this combination can shrink or control the lymphoma.

Suzhou, Jiangsu
NCT06567366Not yet recruiting· Phase 2
Car-t cell therapy with glofitamab for relapsed large b-cell lymphoma

This study tests a combination of CAR-T cell therapy and a drug called glofitamab for people with large B-cell lymphoma that has come back or not responded to treatment. The goal is to see if this combo can help those with high-risk features.

Shanghai
NCT06867536Recruiting· Phase 2
Radiation plus glofitamab for relapsed large B-cell lymphoma with large tumors

This trial tests whether combining a short course of radiation with a targeted antibody drug (glofitamab) can help people with aggressive large B-cell lymphoma that came back after treatment, especially if they have bulky tumors. It aims to find a new option for hard-to-treat cases.

Wuhan, Hubei

Hear when a new Diffuse Large B Cell Lymphoma (DLBCL) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.