Clin2
NCT07327840Possibly a fitActive, not recruiting

Study of Kylo-11 for heart disease with high Lp(a)

Lipoprotein Disorder

Part of Heart & circulation clinical trials.

This trial tests a new drug, Kylo-11, for people with heart or blood vessel disease and high Lp(a), a type of cholesterol that raises risk of heart problems. The study will see if Kylo-11 can help lower that risk.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2
Enrollment
204 people
Ages
18 years to 80 years
Study type
Interventional

Who can take part

  • You are between 18 and 80 years old.
  • You have a diagnosis of atherosclerotic cardiovascular disease (a buildup of plaque in your arteries) and high levels of Lp(a) in your blood.
  • You do not have moderate to severe heart failure or a very weak heart pump.
  • Your blood pressure is well-controlled (under 160/100).
  • You have not had most types of cancer in the last 5 years.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07767513Not yet recruiting· Phase 2
Oral medication for high lp(a) and heart risk

This study tests an oral medication called HRS-5346 to see if it can lower a type of fat in the blood called lipoprotein(a), which is linked to heart disease. If you have high Lp(a) and are at risk for heart problems, this trial may help reduce that risk.

Chengdu, Sichuan
NCT07752069Not yet recruiting· Phase 1
Testing different versions of an experimental medicine in healthy people

This trial compares how well different forms of an experimental drug are absorbed by the body. Healthy volunteers will receive the drug and have blood tests to see which version works best.

Beijing, Beijing Municipality
NCT06980428Recruiting· Phase 1
Safety study of AZD4954 in people with or without high Lp(a)

This trial tests a new drug called AZD4954 for safety. It includes healthy volunteers and people with high Lp(a) or dyslipidemia. The goal is to see if the drug is safe and how the body processes it.

Glendale, California
NCT07613294Recruiting· Phase 3
Testing lepodisiran to reduce heart plaque buildup

This study tests whether a new medicine called lepodisiran can shrink plaque in heart arteries for adults with high Lp(a) (a type of cholesterol linked to heart disease) who have had a heart event or are at serious risk. The trial uses CT scans to monitor changes in your arteries.

La Jolla, California
NCT07640217Not yet recruiting· Phase 2
Study of an injected medicine for high lp(a) in adults

This study tests an investigational medicine given by injection to lower Lp(a), a type of fat linked to heart disease. It may help people with high Lp(a) who already have heart problems or are at increased risk.

NCT06750341Not yet recruiting· Phase 2
Study of a new drug for high cholesterol

This study tests an experimental drug (QLC7401) that may help lower LDL ('bad') cholesterol in people who already have high cholesterol or mixed hyperlipidemia. If you're on stable cholesterol medication but still need more lowering, this trial could offer another option.

Hear when a new Lipoprotein Disorder trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.