Clin2
NCT07328971Possibly a fitRecruiting

Vancomycin taper to prevent C. diff from coming back

Clostridia Difficile Colitis

Treatments studied

Part of Digestive system, Infections clinical trials.

This trial tests whether a gradual decrease (taper) of vancomycin can stop C. diff infections from returning. It’s for adults with their first or second C. diff infection who can take pills by mouth.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
500 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 or older and being treated at a participating hospital.
  • This is your first or second C. diff infection (the second must be within 120 days of the first).
  • You currently have at least 3 loose stools in 24 hours or signs of colon inflammation.
  • You can take medications by mouth.
  • You have not had more than 2 C. diff infections in the past year.
  • You are not pregnant, planning pregnancy, or breastfeeding.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06979609Recruiting· Phase 2/Phase 3
Preventing C. diff infection with vancomycin

This trial tests whether taking vancomycin by mouth can prevent another C. diff infection when you need to take other antibiotics. It’s for patients who recently had C. diff and are about to start a new antibiotic course.

Montreal, Quebec
NCT07120490Not yet recruiting
Comparing treatments for C. diff infection to stop it from returning

This trial compares three treatments for a severe diarrhea infection called C. diff: a fecal transplant (putting healthy donor stool into your gut), a newer antibiotic called fidaxomicin, and an older antibiotic called vancomycin. The goal is to see which works best and prevents the infection from coming back.

NCT05266807Recruiting· Phase 3
Capsule fecal transplant to prevent C. difficile coming back

This study tests whether taking a capsule form of fecal microbiota transplant (FMT) can help adults with their first C. difficile infection—or a first relapse—get better and reduce repeat episodes. Participants also take specific antibiotics for C. difficile as part of the study process.

Basel, Basel
NCT06794944Not yet recruiting· Phase 4
Comparing two antibiotics to clear C. difficile in inflammatory bowel disease

This study tests two antibiotics—fidaxomicin and vancomycin—to see which is better at clearing C. difficile bacteria from the gut in people with inflammatory bowel disease. If you are having a colonoscopy, you may be able to participate.

Boston, Massachusetts
NCT07221370Recruiting· Phase 2/Phase 3
Vancomycin to prevent C. diff infection in ICU patients

This trial tests whether giving vancomycin through a tube into the stomach can prevent a serious gut infection called C. diff in people who are very sick in the ICU and taking antibiotics. If you qualify, you might receive this medicine to lower your risk.

Moreno Valley, California
NCT06306014Recruiting· Phase 1/Phase 2
Study of a new therapy to prevent C. diff recurrence

This study tests a new live bacteria product (EXL01) given with vancomycin to prevent C. diff from coming back. It is for people who have already had C. diff two or more times and are at high risk of another infection.

Annecy

Hear when a new Clostridia Difficile Colitis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.