Clin2
NCT07357597Possibly a fitRecruiting

Preventing mouth sores during breast or lung cancer treatment

Stomatitis

Treatments studied

Part of Mouth & dental clinical trials.

This trial tests whether a steroid mouthwash can prevent mouth sores caused by the drug Datopotamab Deruxtecan (Dato-DXd). It is for people with certain types of advanced breast cancer or lung cancer who are about to start Dato-DXd for the first time.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
100 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You have advanced breast cancer (HR+/HER2- or triple-negative) or advanced lung cancer with an EGFR mutation
  • You have not yet received any dose of Dato-DXd
  • You are willing to use a steroid mouthwash every time you get the drug
  • You are 18 or older and able to care for yourself (ECOG 0 or 1)
  • You do not have active mouth sores or infections in your mouth
  • You are not pregnant or breastfeeding

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07543978Not yet recruiting· Phase 3
Chinese medicine to prevent mouth sores from radiation therapy

This trial tests if traditional Chinese medicine can prevent painful mouth sores caused by radiation therapy for head and neck cancer. If it works, it could reduce pain and help you stay on treatment.

NCT07291037Recruiting· Phase 3
Comparing a new drug to standard chemo for advanced lung cancer

This trial tests a new drug called datopotamab deruxtecan against a standard chemotherapy (docetaxel) for people with a certain type of advanced lung cancer (non-squamous non-small cell lung cancer) that has already been treated. The new drug targets a protein called TROP2 found on cancer cells, which may help slow or stop the cancer's growth.

Chandler, Arizona
NCT06974604Recruiting· Phase 2
Mouthwash to prevent mouth sores from Datopotamab deruxtecan

This trial tests if a dexamethasone mouthwash can prevent painful mouth sores (stomatitis) caused by the cancer drug Datopotamab deruxtecan (Dato-DXd). It's for people with certain types of advanced lung or breast cancer who have already tried other treatments.

Providence, Rhode Island
NCT07287826Recruiting· Phase 4
Steroid mouthwash to prevent mouth sores during chemo

This trial tests if using a steroid mouthwash can prevent painful mouth sores caused by certain chemotherapy drugs. It aims to help patients who are starting or already receiving chemotherapy known to cause mouth sores.

Baton Rouge, Louisiana
NCT06934733Not yet recruiting
Oral ice chips to prevent mouth sores from breast cancer treatment

This trial tests if sucking on ice chips during a new type of breast cancer treatment (TROP2-ADC) can reduce or prevent painful mouth sores. If you are starting this treatment for the first time, this simple approach might help you feel better.

Zhengzhou, Henan
NCT07828054Not yet recruiting· Phase 3
Steroid premedication to protect lungs during breast cancer treatment

This trial tests whether a steroid called dexamethasone, given before T-DXd, can reduce the risk of a rare but serious lung side effect (interstitial lung disease) in people with advanced breast cancer. If it works, it may make treatment safer.

Hear when a new Stomatitis trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.